72351-36-1

Basic information

• Product Name: 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE
• Synonyms: BUTTPARK 37\04-19;1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE;(1-BENZHYDRYLAZETIDIN-3-YL)METHANOL;1-Diphenylmethyl-3-(hydro...;1-(diphenylMethyl)-3-(hydroxyMethyl)azetidine-hcl;[1-(Diphenylmethyl)azetidin-3-yl]methanol;1-Benzhydryl-3-(hydroxymethyl)azetidine;(1-Benzhydrylazetidin-3-yl)
• CAS NO: 72351-36-1
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.34
• Mol File: 72351-36-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 334.5 °C at 760 mmHg
• Flash Point: 139.5 °C
• Appearance: /
• Density: 1.137
• Vapor Pressure: 5.03E-05mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE(72351-36-1)
• EPA Substance Registry System: 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE(72351-36-1)

Safety Data

• Hazardous Substances Data: 72351-36-1(Hazardous Substances Data)

Usage

General Description

1-(Diphenylmethyl)-3-(hydroxymethyl)azetidine is a chemical compound that belongs to the class of azetidines. It has a molecular formula of C17H19NO and a molecular weight of 253.34 g/mol. 1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE is a derivative of azetidine, which is a four-membered heterocyclic ring containing nitrogen. The presence of the diphenylmethyl group and the hydroxymethyl group in the structure make this compound potentially useful for various applications in organic synthesis and medicinal chemistry. Its chemical properties and ability to participate in reactions make it a valuable building block for the design and synthesis of new molecules with specific properties and functions. Additionally, this compound may have biological activities or pharmacological properties that could be explored for potential therapeutic applications.

InChI:InChI=1/C17H19NO/c19-13-14-11-18(12-14)17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,14,17,19H,11-13H2

Upstream product

• 36476-87-6 1-benzhydrylazetidine-3-carboxylic acid 
• 91-00-9 Benzhydrylamine 
• 36476-86-5 1-(1,1-diphenylmethyl)azetidine-3-carbonitrile 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 53871-06-0 1-(diphenylmethyl)-3-methoxycarbonylazetidine 

Downstream Products

• 955400-19-8 1-benzhydryl-3-methoxymethylazetidine 
• 95849-02-8 3-hydroxymethyl-1-azetidine 
• 321890-21-5 [1-(1,1-diphenylmethyl)azetidin-3-ylmethyl]dimethylamine 
• 1266244-56-7 C₂₄H₂₁ClF₃NO 
• 142253-56-3 3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester 
• 162698-41-1 (1-benzhydrylazetidin-3-yl)methyl methanesulfonate 
• 928038-44-2 3-(hydroxymethyl)azetidine hydrochloride 

Relevant articles and documents

Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders

To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.

Process for preparing phenoxypyridine derivatives

A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.