5392-86-9

Basic information

• Product Name: 2,4-dichlorophenetole
• Synonyms: 2,4-dichlorophenetole;2,4-dichloro-1-ethoxybenzene;2,4-Dichlorophenyl(ethyl) ether;2,4-Dichlorophenylethyl ether
• CAS NO: 5392-86-9
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.05452
• EINECS: 226-397-2
• Product Categories: Phenetole
• Mol File: 5392-86-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 32°C
• Boiling Point: 273.74°C (rough estimate)
• Flash Point: 80.9 °C
• Appearance: /
• Density: 1.2559 (rough estimate)
• Vapor Pressure: 0.0627mmHg at 25°C
• Refractive Index: 1.5440 (estimate)
• CAS DataBase Reference: 2,4-dichlorophenetole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichlorophenetole(5392-86-9)
• EPA Substance Registry System: 2,4-dichlorophenetole(5392-86-9)

Safety Data

• Hazardous Substances Data: 5392-86-9(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorophenetole is a chemical compound with the molecular formula C8H8Cl2O. It is a white, crystalline solid that is used primarily as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a solvent in various chemical reactions. 2,4-Dichlorophenetole is classified as a chlorinated aromatic compound and has a strong, sweet odor. It is considered to be moderately toxic and can cause irritation to the skin, eyes, and respiratory system. 2,4-Dichlorophenetole is not highly flammable but should be handled with care and stored in a cool, well-ventilated area away from heat and open flames.

InChI:InChI=1/C8H8Cl2O/c1-2-11-8-4-3-6(9)5-7(8)10/h3-5H,2H2,1H3

Upstream product

• 75-03-6 ethyl iodide 
• 120-83-2 2,4-dichlorophenol 
• 103-73-1 Phenetole 
• 622-61-7 1-chloro-4-ethoxybenzene 
• 109-63-7 boron trifluoride diethyl etherate 
• 120-36-5 2-(2,4-dichlorophenoxy)propionic acid 
• 64-17-5 ethanol 
• 1435-48-9 1,3-dichloro-4-fluorobenzene 

Downstream Products

• 120-83-2 2,4-dichlorophenol 
• 122756-30-3 2,4-dichloro-6-nitro-phenetole 

Relevant articles and documents

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

A new alkylation of aryl alcohols by boron trifluoride etherate

The ethylation of aryl alcohols by an ethyl moiety of boron trifluoride etherate is described. The reaction proceeded cleanly and afforded good yields of the corresponding aryl ethyl ethers. It tolerated the presence of functional groups such as aryl, alkyl, halogens, nitro, nitrile, and amino. However, the presence of amino or nitro groups ortho to a hydroxyl group of an aryl compound drastically reduced the yields of the anticipated products due to the chelation of the aforementioned functional groups with boron trifluoride etherate. A nitrogen atom in the aromatic ring system, as exemplified by hydroxypyridine and 8-hydroxyquinoline, completely inhibited the reaction. Resorcinol, hydroquinone, and aryl alcohols with aldehyde functions decomposed under the reaction conditions.

Studies on catechol esters. I. Synthesis of cyclic succinoylcatechols and o-hydroxyphenyl acid succinates.

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