53956-04-0 Usage
Description
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground
rhizome and root portions of Glycyrrhiza glabra or other species of
glycyrrhiza. Licorice extract is that portion of the licorice root that
is, after maceration, extracted by boiling water. The extract can be
further purified by filtration and by treatment with acids and ethyl
alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried
powder. (2) Ammoniated glycyrrhizin is prepared from the
water extract of licorice root by acid precipitation followed by neutralization
with dilute ammonia. Monoammonium glycyrrhizinate
(C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by
solvent extraction and separation techniques.
Chemical Properties
Different sources of media describe the Chemical Properties of 53956-04-0 differently. You can refer to the following data:
1. Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
2. white to slightly yellow powder
Uses
Different sources of media describe the Uses of 53956-04-0 differently. You can refer to the following data:
1. Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl
ammatory drugs with which Ammonium Glycyrrhizinate is associated.
2. pharmaceutical excipient, GRAS, sweetener
3. Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
General Description
Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate.
Biochem/physiol Actions
Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.
Anticancer Research
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety Profile
Moderately toxic by
intravenous route. An experimental
teratogen. Experimental reproductive
effects. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NH3.
Purification Methods
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
Check Digit Verification of cas no
The CAS Registry Mumber 53956-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,5 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 53956-04:
(7*5)+(6*3)+(5*9)+(4*5)+(3*6)+(2*0)+(1*4)=140
140 % 10 = 0
So 53956-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21?,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
53956-04-0Relevant articles and documents
Clear liquid skin cosmetic compositions
-
, (2008/06/13)
Disclosed is a clear liquid skin cosmetic composition (e.g., a lotion) in which one or more oily substances (such as oil-soluble perfumes, hormones and the like) are solubilized in water with the aid of a solubilizing agent comprising an 18α-glycyrrhizin (18α-glycyrrhizic acid sodium salt, potassium salt or ammonium salt) that is a novel compound derived from a conventional glycyrrhizin (i.e., any form of 18β-glycyrrhizin extracted from licorice root) or a glycyrrhizin composition consisting of an 18α-glycyrrhizin and an 18β-glycyrrhizin. This skin cosmetic composition is not irritative to the skin as contrasted with skin cosmetic compositions prepared by using a synthetic surface-active agent as the solubilizing agent, and is not subject to gelation in a slightly acidic to acidic pH range as contrasted with skin cosmetic compositions prepared by using an 18β-glycyrrhizin alone as the solubilizing agent. Moreover, this skin cosmetic composition exerts a mild action on the skin without causing irritation thereto, gives an agreeable feeling, and has excellent fluidity, usability and storage stability.
