5398-16-3

Basic information

• Product Name: 2-(4-methylbenzyl)benzoic acid
• CAS NO: 5398-16-3
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.2705
• Mol File: 5398-16-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.7°C at 760 mmHg
• Flash Point: 176°C
• Density: 1.144g/cm³
• Vapor Pressure: 2.23E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(4-methylbenzyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylbenzyl)benzoic acid(5398-16-3)
• EPA Substance Registry System: 2-(4-methylbenzyl)benzoic acid(5398-16-3)

Safety Data

• Hazardous Substances Data: 5398-16-3(Hazardous Substances Data)

Usage

General Description

2-(4-methylbenzyl)benzoic acid, also known as 4-methylbenzyl benzoic acid, is an organic compound that belongs to the class of aromatic carboxylic acids. It is a white crystalline solid with a molecular formula of C15H14O2 and a molecular weight of 226.27 g/mol. 2-(4-methylbenzyl)benzoic acid is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of fragrances, dyes, and other organic compounds. Additionally, 2-(4-methylbenzyl)benzoic acid has been studied for its potential anti-inflammatory and antioxidant properties. Overall, this compound has a variety of industrial and research applications due to its unique chemical structure and properties.

Upstream product

• 124-38-9 carbon dioxide 
• 67104-71-6 1-bromo-2-(4-methylbenzyl)benzene 
• 21615-75-8 3-(4-tolyl)-isobenzofuranone 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 624-31-7 4-tolyl iodide 
• 85-44-9 phthalic anhydride 
• 85-55-2 2-(4-toluoyl)benzoic acid 
• 7664-41-7 ammonia 
• 108-88-3 toluene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59142-66-4 (2-bromophenyl)(p-tolyl)methanol 

Downstream Products

• 21615-75-8 3-(4-tolyl)-isobenzofuranone 
• 103442-22-4 2-methyl-9-phenyl-anthracene 
• 102310-87-2 2-methyl-9-phenyl-9,10-dihydro-anthracene 
• 37459-57-7 3-(4-Methylphenyl)-1-oxo-2,3-dihydroisoindol 
• 10324-07-9 2-<(4-methylphenyl)methyl>phenylacetic acid 
• 10324-27-3 [2-(4-Methyl-benzyl)-phenyl]-acetonitrile 
• 10324-28-4 C₁₅H₁₅Br 
• 94001-43-1 o-(p-Methyl-benzyl)-benzylalkohol 
• 84-54-8 2-methylanthracene-9,10-dione 

Relevant articles and documents

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Direct Synthesis of γ-Substituted Phthalides Via ortho-Aryl Benzoic Acid Mediated Benzyl Radical Cyclization

Direct synthesis of γ-substituted phthalids from related ortho-aryl benzoic acids with 48-85% yield are covered. The direct oxidation in the presence of peroxydisulphate-copper (II) chloride in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to γ-butyrolactone, through very stable benzylic radical intermediate.

Reductive cleavage of phthalides with iodotrimethylsilane

A convenient reductive cleavage of 3-arylphthalides 1 into corresponding 2-benzylbenzoic acids and 2-(2-thienylmethyl)benzoic acid 2 by using iodotrimethylsilane is described.