59142-66-4

Basic information

• Product Name: Benzenemethanol, 2-bromo-a-(4-methylphenyl)-
• CAS NO: 59142-66-4
• Molecular Formula: C14H13BrO
• Molecular Weight: 277.161
• Mol File: 59142-66-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-bromo-a-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-bromo-a-(4-methylphenyl)-(59142-66-4)
• EPA Substance Registry System: Benzenemethanol, 2-bromo-a-(4-methylphenyl)-(59142-66-4)

Safety Data

• Hazardous Substances Data: 59142-66-4(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 67104-64-7 2-bromophenyl(4-methylphenyl)methanone 
• 5084-80-0 tri(4-tolyl)boroxine 
• 106-38-7 para-bromotoluene 

Downstream Products

• 1200768-01-9 (2-bromophenyl)(p-tolyl)methyl acetate 
• 67104-64-7 2-bromophenyl(4-methylphenyl)methanone 
• 15832-68-5 (S)-neobenodine 
• 2523-39-9 3-methylfluorene 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 170632-41-4 1-benzyl-3-(4'-ethoxycarbonylphenyl)indazole 
• 886755-45-9 3-(4-ethoxycarbonylphenyl)indazole 
• 746651-78-5 ethyl 4-(2-bromobenzoyl)benzoate 
• 1134949-07-7 1-bromo-2-[1-(4-methylphenyl)ethenyl]benzene 
• 59142-73-3 1-bromo-2-(methoxy-p-tolyl-methyl)-benzene 
• 59142-74-4 1'-benzyl-3-p-tolyl-3H-spiro[isobenzofuran-1,4'-piperidine] 
• 5398-16-3 2-(4-methyl-benzyl)-benzoic acid 
• 67104-71-6 1-bromo-2-(4-methylbenzyl)benzene 

Relevant articles and documents

Preparation method of indazole and application of indazole in medicine synthesis

The invention belongs to the field of chemicals, and relates to a preparation method of indazole and an application of the indazole in medicine synthesis. The invention discloses a preparation method of indazole and an application of the indazole in synthesizing 1H-indazole-3-carboxylic acid, lonidamine, a compound 8, a compound 9, a compound 10, axitinib, YD-3, YC-1 and similar substances thereof.

Efficient palladium-catalyzed C(sp2)-H activation towards the synthesis of fluorenes

A facile protocol for the synthesis of fluorene derivatives has been developed through palladium-catalyzed cyclization of 2′-halo-diarylmethanes via activation of arylic C-H bonds. The reactions occurred smoothly and allowed both electron-rich and electron-deficient substrates to convert into their corresponding fluorenes in good to excellent yields. Studies revealed that this Pd-catalyzed cyclization was also available for the substrates of 2′-chloro-diarylmethanes and no catalyst poisoning occurred for 2′-iodo-diphenylmethane.

CuII-catalyzed asymmetric hydrosilylation of diaryl- and aryl heteroaryl ketones: Application in the enantioselective synthesis of orphenadrine and neobenodine

With certain amounts of sodium tert-butoxide and tert-butanol as additives, catalytic amounts of an inexpensive and easy-to-handle copper source Cu(OAc)2·H2O, a commercially available and air-stable non-racemic dipyridylphosphine ligand, as well as the stoichiometric desirable hydride donor polymethylhydrosiloxane (PMHS), formed a versatile in situ catalyst system for the enantioselective reduction of a broad spectrum of prochiral diaryl and aryl heteroarylketones in air, in high yields and with good to excellent enantioselectivities (up to 96 %). In particular, the practical viability of this process was evinced by its successful applications in the asymmetric synthesis of optically enriched potent antihistaminic drugs orphenadrine and neobenodine. Copyright