5399-30-4

Basic information

• Product Name: PHENACYL THIOCYANATE
• Synonyms: 2-Oxo-2-phenylethyl thiocyanate;PHENACYL THIOCYANATE;2-Phenyl-2-oxoethyl thiocyanate;Thiocyanic acid phenacyl ester;α-(Cyanothio)acetophenone;α-Thiocyanatoacetophenone;β-Oxophenethyl thiocyanate;thiocyanic acid (2-keto-2-phenyl-ethyl) ester
• CAS NO: 5399-30-4
• Molecular Formula: C₉H₇NOS
• Molecular Weight: 177.22
• EINECS: 604-604-1
• Mol File: 5399-30-4.mol
• Article Data: 75

Chemical Properties

• Melting Point: 74.1-74.6 °C
• Boiling Point: 331.5 °C at 760 mmHg
• Flash Point: 154.3 °C
• Appearance: /
• Density: 1.223 g/cm³
• Water Solubility: 349.4mg/L(22 oC)
• CAS DataBase Reference: PHENACYL THIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENACYL THIOCYANATE(5399-30-4)
• EPA Substance Registry System: PHENACYL THIOCYANATE(5399-30-4)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5399-30-4(Hazardous Substances Data)

Upstream product

• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 333-20-0 potassium thioacyanate 
• 98-86-2 acetophenone 
• 302-04-5 Thiocyanate 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 1147550-11-5 ammonium thiocyanate 
• 100-42-5 styrene 
• 536-74-3 phenylacetylene 
• 15192-76-4 copper(II) thiocyanate 
• 146120-04-9 1-[amino(thioxo)methyl]-5-hydroxy-3-methyl-1H-pyrazole 
• 20187-61-5 mesyloxyacetophenone 
• 1124-15-8 3,5-dimethyl-1H-pyrazole-1-carbothioamide 
• 35290-52-9 2-[amino(thioxo)methyl]-5-methyl-2,3-dihydro-1H-3-pyrazolone 

Downstream Products

• 2103-88-0 4-phenylthiazole-2(3H)-thione 
• 38650-46-3 3,4-diphenyl-2-imino-4-thiazoline 
• 79307-55-4 2-methoxy-4-phenylthiazole 
• 130672-49-0 7-methoxy-1-phenyl-thiazolo[3,2-a]quinazolin-5-one 
• 873998-49-3 thiocarbamic acid S-phenacyl ester 
• 1826-23-9 2-chloro-4-phenylthiazole 
• 59229-28-6 5-phenyl-4⁽⁶⁾H-[1,3,4]thiadiazin-2-ylamine 
• 59775-62-1 4-(5-benzoyl-2-imino-[1,3,4]thiadiazol-3-yl)-benzoic acid 
• 123342-63-2 1,3-Diphenyl-2-thiocyanato-3-p-tolylamino-propan-1-one 
• 123342-58-5 1,3-Diphenyl-3-phenylamino-2-thiocyanato-propan-1-one 
• 245355-51-5 3-acetyl-4-phenyl-3H-thiazol-2-one 
• 110553-73-6 phenyl-glyoxal-bis-(4-sulfamoyl-phenylhydrazone) 
• 62-53-3 aniline 
• 124-38-9 carbon dioxide 

Relevant articles and documents

A new stereoselective synthesis of 2-amino-4,5-dihydrothiophene-3- carbonitrile derivatives

A new stereoselective method for the synthesis of trans-isomers of 2-amino-4-aryl-5-benzoyl-4,5-dihydrothiophene-3-carbonitriles was proposed. The method involves base-catalyzed reactions of phenacyl thiocyanate with 3-(het)aryl-2-cyanoprop-2-enethioamides. (4R,5S/4S,5R)-2-Amino-5-benzoyl-4-(2- chlorophenyl)-4,5-ihydrothiophene-3-carbonitrile was structurally characterized by X-ray diffraction analysis.

Visible-Light-Mediated Additive-Free Decarboxylative Ketonization Reaction of Acrylic Acids: An Access to α-Thiocyanate Ketones

Visible-light-mediated additive-free decarboxylative functionalization of acrylic acids has been developed. The reaction uses inexpensive organic dye 9,10-dicyanoanthracene as a photocatalyst and uses the ubiquitous dioxygen as both an oxygen source and an oxidant. Through this mild and environmentally friendly method, a series of important α-thiocyanate ketones can be generated from easily available acrylic acids and ammonium thiocyanate. In addition, the facile transformation of product α-thiocyanate ketones makes this method have great potential for application in organic and pharmaceutical chemistry.

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

Boron-doped TiO2(B-TiO2): visible-light photocatalytic difunctionalization of alkenes and alkynes

Boron-doped TiO2(B-TiO2) was prepared, characterized, and successfully applied as a reusable, inexpensive, available, and heterogeneous nanophotocatalyst under visible light for a novel method of construction of phenacyl thiocyanate compounds from double or triple bonds. Impressive aspects of this project are obtaining the desired compounds in a short time, using a renewable energy source, and using a catalyst with easy extraction that is solvent-safe, and without the use of any oxidants, bases, and ligands, or harsh conditions. This is the first report of the construction of phenacyl thiocyanates through this photocatalytic method under visible light.