54007-06-6

Basic information

• Product Name: (3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinato)iron(III)
• Synonyms: (3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinato)iron(III)
• CAS NO: 54007-06-6
• Molecular Weight: 656.498
• Mol File: 54007-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinato)iron(III)(CAS DataBase Reference)
• NIST Chemistry Reference: (3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinato)iron(III)(54007-06-6)
• EPA Substance Registry System: (3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinato)iron(III)(54007-06-6)

Safety Data

• Hazardous Substances Data: 54007-06-6(Hazardous Substances Data)

Upstream product

• 49744-73-2 3-hydroxy-2-methyl-1-phenyl-4-pyridinone 

Relevant articles and documents

Synthesis, characterization, and cytotoxicity studies of Cu(II), Zn(II), and Fe(III) complexes of N-derivatized 3-hydroxy-4-pyridiones

The deleterious role of metal ions in Alzheimer's disease has inspired the study of various metal chelators. We previously showed the synthesis and in vitro activity of several bidentate hydroxypyridinone compounds, including 3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinone (1), 1-(4-aminophenyl)-3-hydroxy-2- methyl-4(1H)-pyridinone (2), and 1-(2-benzothiazolyl)-3-hydroxy-2-methyl-4(1H)- pyridinone (3). While the focus has been on the Cu(II) ion, the other biorelevant metals, Zn(II) and Fe(III) have been largely neglected. Herein, we report the synthesis of Zn(II) and Fe(III) complexes of ligands 1, 2, and 3, and their characterization by infrared (IR) spectroscopy, high resolution mass spectrometry (HR-MS), elemental analysis, and NMR, where applicable. Solid state structures of Zn(1)2, Fe(1)3, and Cu(3)2 are analyzed with X-ray crystallography. The cytotoxicity of pro-ligands 1, 2, and 3, and the three metal complexes of 2 are examined in a neuronal cell line to determine the effect of metal chelation on toxicity of the compounds.