5415-07-6

Basic information

• Product Name: 3-Oxo-2,3-diphenylpropanenitrile
• Synonyms: 3-Oxo-2,3-diphenylpropanenitrile;α-Benzoylphenylacetonitrile;α-Phenyl-β-oxobenzenepropanenitrile;b-Oxo-a-phenyl-benzenepropanenitrile
• CAS NO: 5415-07-6
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.27
• Mol File: 5415-07-6.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 362.31°C (rough estimate)
• Flash Point: 184.3°C
• Appearance: /
• Density: 1.0966 (rough estimate)
• Vapor Pressure: 5.18E-06mmHg at 25°C
• Refractive Index: 1.6283 (estimate)
• CAS DataBase Reference: 3-Oxo-2,3-diphenylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxo-2,3-diphenylpropanenitrile(5415-07-6)
• EPA Substance Registry System: 3-Oxo-2,3-diphenylpropanenitrile(5415-07-6)

Safety Data

• Hazardous Substances Data: 5415-07-6(Hazardous Substances Data)

Usage

Safety Profile

A poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.

InChI:InChI=1/C15H11NO/c16-11-14(12-7-3-1-4-8-12)15(17)13-9-5-2-6-10-13/h1-10,14H

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 140-29-4 phenylacetonitrile 
• 613-90-1 benzoyl cyanide 
• 60-29-7 diethyl ether 
• 93-89-0 benzoic acid ethyl ester 
• 141-52-6 sodium ethanolate 
• 100-47-0 benzonitrile 
• 26388-11-4 Natrium-phenylacetonitril 
• 98-88-4 benzoyl chloride 
• 64-17-5 ethanol 
• 26087-01-4 2-azido-1,3-diphenylpropen-1-one 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 116730-29-1 5,6-diphenyl-pyrimidine-2,4-diyldiamine 
• 33238-92-5 2,5,6-triphenylpyrimidin-4-amine 
• 4686-15-1 β-Anilino-α-phenylcinnamonitrile 
• 102469-75-0 5-amino-1,3,4-triphenyl-1H-pyrazole 
• 54108-62-2 3-Oxo-2,3-diphenylpropenoic acid methyl ester 
• 854869-26-4 3-amino-1,2,3-triphenyl-propenone 
• 113056-76-1 6-methyl-3,4,5-triphenyl-pyridin-2-ol 
• 103164-44-9 6-benzyl-3,4,5-triphenyl-pyridin-2-ol 
• 451-40-1 phenyl benzyl ketone 
• 63633-46-5 3,4-diphenyl-1H-pyrazol-5-amine 
• 52392-73-1 5-amino-3,4-diphenylisoxazole 
• 35061-99-5 3-Oxo-2,3-diphenyl-propionamide 
• 51954-59-7 tetraphenyl-pyridin-2-ol 
• 41278-43-7 3-amino-2,3-diphenylacrylonitrile 

Relevant articles and documents

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and codelet

INHIBITORS OF CELLULAR METABOLIC PROCESSES

The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.

Synthesis of β-ketonitriles, α,β-alkynones and biscabinols from esters using tert-butoxide-assisted C(=O)-C (i.e., acyl-C) coupling under ambient conditions

We demonstrated the synthesis of β-ketonitriles, α,β- alkynones, and biscarbinols using tert-butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters under ambient conditions. tert-Butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters with cyanomethylenes and acetylenes under transition metal-free ambient conditions gives β-ketonitriles, α,β-alkynones and/or aryl bis(phenylethynyl)carbinols in moderate-to-good yields. It is noteworthy that this is a rapid, facile, and efficient process under ambient conditions, and use of cheap and stable starting materials.