5428-50-2Relevant articles and documents
Novel synthesis and biological evaluations of N,N’-disubstituted-3,6-bis(substitutedphenyl)-1,2,4,5-tetrazine-1,4-dicarboxamide
Tong, Guo-Tong,Lv, Lu-Ping,Tang, Ping,Li, Wei-Wei
, p. 335 - 342 (2018/06/06)
A series of novel N,N’-disubstituted-3,6-bis(substitutedphenyl) -1,2,4,5-tetrazine-1,4-dicarboxamides were prepared using the intermolecular cyclization reaction of N-substituted-N’-(α-chloro-substitutedbenzylidene) hydrazinecarboxamide and triethylamine by the modification of solvent polarity. The structures of all the new compounds were characterized by IR, 1H-NMR, MS and elemental analysis. Their cytostatic effects were screened in vitro by the SRB method for A-549 cell and the MTT method for P-388 cell. The results showed that several compounds demonstrate potential antitumor activities against P-388. The substituents have clearly effect on their antitumor activity.