- Novel synthesis and biological evaluations of N,N’-disubstituted-3,6-bis(substitutedphenyl)-1,2,4,5-tetrazine-1,4-dicarboxamide
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A series of novel N,N’-disubstituted-3,6-bis(substitutedphenyl) -1,2,4,5-tetrazine-1,4-dicarboxamides were prepared using the intermolecular cyclization reaction of N-substituted-N’-(α-chloro-substitutedbenzylidene) hydrazinecarboxamide and triethylamine by the modification of solvent polarity. The structures of all the new compounds were characterized by IR, 1H-NMR, MS and elemental analysis. Their cytostatic effects were screened in vitro by the SRB method for A-549 cell and the MTT method for P-388 cell. The results showed that several compounds demonstrate potential antitumor activities against P-388. The substituents have clearly effect on their antitumor activity.
- Tong, Guo-Tong,Lv, Lu-Ping,Tang, Ping,Li, Wei-Wei
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p. 335 - 342
(2018/06/06)
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- Selective and facile oxidative desulfurization of thioureas and thiobarbituric acids with singlet molecular oxygen generated from trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane
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An efficient and facile procedure using trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane has been developed for oxidative desulfurization of thioureas and thiobarbituric acids. The reactions proceeded smoothly very fast under mild conditions in basic media at room temperature to afford the respective ureas in excellent yields. Simple procedure and work up, mild conditions, high yields, short reaction times, use of highly potent and non-toxic oxidant are the main merits of the present method.
- Azarifar, Davood,Golbaghi, Maryam
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