5428-57-9Relevant articles and documents
Preparation method of high purity acetyl biphenyl
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Paragraph 0032; 0033, (2018/03/24)
The invention relates to a preparation method of a high purity biphenyl acetic acid intermediate namely acetyl biphenyl (I). The preparation method is characterized in that 4-dimethylaminopyridine is taken as the catalyst, and biphenyl and acetic anhydride carry out Friedel-Crafts acylation reactions to generate acetyl biphenyl (I). The method has the advantages that 4-dimethylaminopyridine is taken as the catalyst, the obtained product purity is high, the byproducts are few, the purity can reach 99%, the refinement is not needed, and the yield is increased. The impurities are eliminated, so the impurities will not participate in the subsequent reactions and the final product will not contain the impurities. Acetyl biphenyl and morpholine carry out condensation reactions. Finally, the reaction product is saponified and acidified to obtain a crude product. The crude product is refined for once, and the purity can reach 100%. The multiple refinements are eliminated. The product better satisfies the pharmaceutical requirements. The quality of biphenyl acetic acid is improved. The cost is reduced. The total yield is increased from 63-65% to 75-80%.
Solvent-free synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents using KF-Al2O3 under microwave irradiation
Saeidian, Hamdollah,Sadeghi, Azam,Mirjafary, Zohreh,Moghaddam, Firouz Matloubi
, p. 2043 - 2053 (2008/09/21)
The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported. Copyright Taylor & Francis Group, LLC.
A versatile one-pot synthesis of 2,3,5-tri-substituted thiophenes from thiomorpholides
Matloubi Moghaddam, Firouz,Zali-Boinee, Hassan
, p. 6253 - 6255 (2007/10/03)
An efficient method for the preparation of 2,3,5-trisubstituted thiophenes in a one-pot synthesis from thiomorpholides via the thio-Claisen rearrangement was developed.