5434-27-5Relevant articles and documents
METHYLENEDIMAGNESIUM DIBROMIDE AS PRECURSOR OF METAL CARBENE COMPLEXES; PREPARATION OF TITANACYCLOBUTANES.
Bruin, J. W.,Schat, G.,Akkerman, O. S.,Bickelhaupt, F.
, p. 3935 - 3936 (1983)
The reaction of CH2(MgBr)2 with Cp2TiCl2 gives a titanium methylene complex which, similar to Tebbe's reagent, forms four-membered titana-heterocycles with alkenes and alkines.
1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction
Essiz, Sel?uk,Da?tan, Arif
, p. 150 - 156 (2019/05/16)
An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine (PPh 3) /1,2-dibromotetrachloroethane (DBTCE) complex in excellent yields and very short time (5 min). This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh 3 /DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.
PYRAZOLE AMIDE DERIVATIVE
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Page/Page column 100, (2015/09/28)
The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.