5446-46-8

Basic information

• Product Name: BENZOYL-DL-A-ALANINE ETHYL ESTER
• Synonyms: BENZOYL-DL-A-ALANINE ETHYL ESTER
• CAS NO: 5446-46-8
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.25
• Mol File: 5446-46-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 393.7°C at 760 mmHg
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 2.09E-06mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: BENZOYL-DL-A-ALANINE ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOYL-DL-A-ALANINE ETHYL ESTER(5446-46-8)
• EPA Substance Registry System: BENZOYL-DL-A-ALANINE ETHYL ESTER(5446-46-8)

Safety Data

• Hazardous Substances Data: 5446-46-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 117, 1982 DOI: 10.1016/S0040-4039(00)97549-X

InChI:InChI=1/C12H15NO3/c1-3-16-12(15)9(2)13-11(14)10-7-5-4-6-8-10/h4-9H,3H2,1-2H3,(H,13,14)

Upstream product

• 90839-54-6 C₁₂H₁₁⁽²⁾HNO₄^(1-)*Na⁽¹⁺⁾ 
• 90839-53-5 sodium 2-formylhippurate 
• 1499-53-2 ethyl hippurate 
• 64-17-5 ethanol 
• 235096-50-1 ethyl 2-azido-2-methyl-3-oxo-3-phenylpropanoate 
• 71754-74-0 ethyl 2-azidopropanoate 
• 65-85-0 benzoic acid 
• 90839-57-9 C₁₉H₁₆⁽²⁾HNO₅ 
• 90839-55-7 ethyl (Z)-3-benzoyloxy-2-benzamidoacrylate 
• 2198-64-3 N-Benzoylalanine 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 17344-99-9 AlaOEt 
• 98-88-4 benzoyl chloride 
• 105-57-7 diethyl acetal 

Downstream Products

• 861303-66-4 N-(2-ethyl-2-hydroxy-1-methyl-butyl)-benzamide 
• 860554-59-2 N-(2-benzyl-2-hydroxy-1-methyl-3-phenyl-propyl)-benzamide 
• 33318-76-2 2-phenyl-4-methyl-5-ethoxy-1,3-oxazole 
• 24250-70-2 DL-N-benzoylalaninamide 
• 15366-27-5 N-benzoyl-alanine hydrazide 
• 6304-98-9 N-(1-(phenylcarbamoyl)ethyl)benzamide 
• 74185-87-8 (+)-trans-1,4-diphenyl-3-N-(benzoylamino)-3-methylazetidin-2-one 
• 109502-85-4 N-benzoyl-N'-(N-benzoyl-alanyl)-hydrazine 
• 15366-23-1 N,N'-bis-(N-benzoyl-alanyl)-hydrazine 
• 32619-69-5 L-Alanine, N-benzoyl-, ethyl ester 
• 43008-70-4 N-benzoyl-D-alanine ethyl ester 

Relevant articles and documents

Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

Our aim was to identify new multi-target compounds endowed with both anti-inflammatory and anti-bacterial activities for treatment of human infections. Diflunisal, a nonsteroidal anti-inflammatory agent, has recently been repurposed for its anti-virulence properties against methicillin-resistant Staphylococcus aureus. Effective synthesis of some aza-analogs of the anti-inflammatory drug diflunisal was carried out following the route involving key oxazole intermediates to obtain o- and m-hydroxypyridinecarboxylic acid derivatives. The newly synthesized diflunisal aza-analogs did not exhibit cytotoxic activity up to 80 μM and some of them exhibited anti-inflammatory activities, decreasing the levels of pro-inflammatory cytokines and prostaglandins induced by bacterial lipopolysaccharide in human primary macrophages. Ten of the diflunisal aza-analogs were found to have interesting antibacterial activity, sensitizing S. aureus, Streptococcus pyogenes, Enterococcus faecium, and Pseudomonas aeruginosa to the antibacterial effects of beta-lactam antibiotics and protein synthesis inhibitors.

Amidoearbonylation of aldehydes utilizing cobalt oxide-supported gold nanoparticles as a heterogeneous catalyst

Cobalt oxide-supported gold-nanoparticles-catalyzed transformation of aldehydes and their equivalents to N-acyl-α-arnino acids was achieved. The desired products were obtained in moderate to excellent yields under milder reaction conditions than previous reports employing octacarbonyldicobalt as a catalyst. Copyright

Compounds having an aryltriazine structure

A compound having an aryltriazine structure selected from those of formula (I): STR1 for which the meaning of the substituents Ar, R1, R5, R6, and R6 ' is given in the description. The compound of the invention is useful as medicinal product for disorders associated with a cholinergic dysfunction.