5459-35-8

Basic information

• Product Name: ETHYL 2-BROMOACRYLATE
• Synonyms: ETHYL 2-BROMOACRYLATE;2-bromoacrylic acid ethyl ester;ethyl 2-bromoprop-2-enoate;alpha-Bromoacrylic acid ethyl ester;Ethyl alpha-bromoacrylate;NSC 24148
• CAS NO: 5459-35-8
• Molecular Formula: C₅H₇BrO₂
• Molecular Weight: 179.01
• EINECS: 200-589-5
• Mol File: 5459-35-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 156.5 °C at 760 mmHg
• Flash Point: 52.2 °C
• Appearance: /
• Density: 1.554g/cm³
• Vapor Pressure: 2.88mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: ETHYL 2-BROMOACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-BROMOACRYLATE(5459-35-8)
• EPA Substance Registry System: ETHYL 2-BROMOACRYLATE(5459-35-8)

Safety Data

• Hazardous Substances Data: 5459-35-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-bromoacrylate is a chemical compound with the molecular formula C5H7BrO2. It is a colorless liquid with a pungent odor, primarily used as a reagent in organic synthesis. Ethyl 2-bromoacrylate is known for its strong electrophilic nature, making it useful in reactions such as the Michael addition and the Wittig reaction. It is also an important intermediate in the production of pharmaceuticals and agrochemicals. However, it is important to handle ethyl 2-bromoacrylate with caution, as it is corrosive and harmful if swallowed or inhaled. Proper safety measures should be taken when handling and using this chemical.

InChI:InChI=1/C5H7BrO2/c1-3-8-5(7)4(2)6/h2-3H2,1H3

Upstream product

• 111-65-9 octane 
• 2678-54-8 ketene diethyl acetal 
• 75-65-0 tert-butyl alcohol 
• 74-95-3 1,1-dibromomethane 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 140-88-5 ethyl acrylate 
• 74-96-4 ethyl bromide 

Downstream Products

• 56685-62-2 ethyl 2-(phenylsulfanyl)acrylate 
• 75717-35-0 ethyl (E)-3-(phenylthio)-2-propenoate 
• 77873-87-1 ethyl 2-bromo-3-phenylthiopropanoate 
• 77873-88-2 ethyl 2,3-diphenylthiopropanoate 
• 882-33-7 diphenyldisulfane 
• 839-39-4 cyclopropane-1,1,2-tricarboxylic acid triethyl ester 
• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 409359-85-9 2-(2-methylphenyl)propenoic acid ethyl ester 
• 128839-68-9 2-(4-methylphenyl)propenoic acid ethyl ester 
• 331779-03-4 ethyl 2-(4-bromophenyl)propenoate 
• 39729-00-5 2-(4-methoxyphenyl)propenoic acid ethyl eter 
• 409359-86-0 ethyl 2-(4-cyanophenyl)propenoate 
• 72800-63-6 ethyl ester of α-(p-nitrophenyl)acrylic acid 
• 34943-06-1 1-benzylaziridine-2-carboxylic acid ethyl ester 

Relevant articles and documents

A SIMPLE SYNTHESIS OF 2-AZIDO-2-ALKENOATES

The title compounds are derived from 2,3-dibromoalkanoates by treatment with 3 equivalents of sodium azide.

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, Ra, Rb, Q1, and Q2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.