5470-11-1 Usage
Description
Hydroxylamine hydrochloride is a versatile reducing agent that is commonly used for various applications, including the deacetylation of SATA to form free sulfhydryls, cleavage of protein cross-linkers containing carbonyl groups, and mutagenesis of plasmid DNA. It is also capable of converting aldehydes and ketones to their oxime derivatives in weak bases, making it effective in cleaving cross-linkers and other compounds with carbonyl groups.
Uses
Used in Organic Synthesis:
Hydroxylamine hydrochloride is used as a monomamine oxidase inhibitor and serves as a key starting material for the preparation of pharmaceuticals and agrochemicals. It is also used to prepare oximes and hydroxamic acids in organic synthesis.
Used in Polymerization Processes:
In the polymerization industry, hydroxylamine hydrochloride acts as a copolymerization inhibitor, playing a crucial role in controlling the polymerization process.
Used in Rubber and Plastic Industries:
Hydroxylamine hydrochloride is utilized as an antioxidant, vulcanization accelerator, and radical scavenger in the rubber and plastic industries, contributing to the stability and quality of the final products.
Used in Photography:
As a reducing agent, hydroxylamine hydrochloride is employed in the photography industry to facilitate specific reactions and processes.
Used in Synthetic and Analytical Chemistry:
Hydroxylamine hydrochloride is used in controlled reduction reactions and as a reagent for enzyme reactivation in synthetic and analytical chemistry.
Used in Textiles:
In the textile industry, hydroxylamine hydrochloride serves as an antioxidant for fatty acids and soaps, enhancing the quality and longevity of textile products.
Used in Medicine:
Hydroxylamine hydrochloride is used in medicine for various applications, including as a reducing agent in controlled reduction reactions and as a reagent for enzyme reactivation.
Used in Lignin Extraction:
It can be used to remove bromine and polybromide from a solution during the extraction of lignin from lignocellulosic biomass, which is an essential process in the production of biofuels and other bio-based products.
Used in Floor Lacquers:
Hydroxylamine hydrochloride is utilized as an antioxidant in floor lacquers, ensuring the protection and longevity of the lacquer coating.
Preparation
Sodium nitrite synthesis method (oximation method) Add water to the reaction kettle, add sodium nitrite under stirring, add sodium metabisulfite in stages, and then acidify with sulfuric acid. The acidified material is sent to the hydrolysis kettle, acetone is added, neutralized with liquid caustic soda, and the neutralized liquid is distilled to obtain acetone oxime. Acetone oxime and hydrochloric acid are added to the salt-forming kettle for reaction to generate hydroxylamine hydrochloride and acetone. Acetone is recovered and used; hydroxylamine hydrochloride is concentrated, crystallized by cooling, centrifuged and dried to obtain the finished product. Raw material consumption quota: sodium nitrite (95%) 1970kg/t, sodium metabisulfite (64% as SO2) 5418kg/t, acetone (98%) 1175kg/t. 2. Nitromethane method Nitromethane reacts with hydrochloric acid and water to obtain hydroxylamine hydrochloride. According to HGB3044-76, the hydroxylamine hydrochloride product is white crystal, the content of the second-grade product is ≥98.5, and the content of the third-grade product is ≥97%. Raw material consumption quota: nitromethane 1200kg/t, hydrochloric acid (30%) 1500kg/t. Or by the action of nitromethane with hydrochloric acid and water to obtain hydroxylamine hydrochloride.
Preparation
Hydroxylamine hydrochloride is prepared by electrolytic reduction ofammonium chloride.
Air & Water Reactions
Hygroscopic. Sensitive to prolonged exposure to air. Water soluble. Reacts slowly with water.
Reactivity Profile
A powerful reducing agent. Reacts with bases and oxidizing agents.
Fire Hazard
Flash point data for Hydroxylamine hydrochloride are not available; however, Hydroxylamine hydrochloride is probably combustible.
Flammability and Explosibility
Notclassified
Biochem/physiol Actions
MAO inhibitor; inhibits platelet aggregation.
Contact allergens
Hydroxylamine and its salts are used in various
branches of industry, as reducing agents in color film
developers or as reagents in laboratories.
Purification Methods
Crystallise the salt from aqueous75% ethanol or boiling methanol, and dry it under vacuum over CaSO4 or P2O5. It has also been dissolved in a minimum of water and saturated with HCl; after three such crystallisations, it is dried under a vacuum over CaCl2 and NaOH. Its solubility at 20o is 85% in H2O, 6% in EtOH and 12% in MeOH. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1941.]
Check Digit Verification of cas no
The CAS Registry Mumber 5470-11-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,7 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5470-11:
(6*5)+(5*4)+(4*7)+(3*0)+(2*1)+(1*1)=81
81 % 10 = 1
So 5470-11-1 is a valid CAS Registry Number.
InChI:InChI=1/ClH.H3NO/c;1-2/h1H;2H,1H2
5470-11-1Relevant articles and documents
Pauling, L.,Hendricks, S. B.
, p. 641 - 651 (1926)
Rollefson, G. K.,Oldershaw, C. F.
, p. 977 (1932)
MAGNETIC NANOSTRUCTURES AS THERANOSTIC AGENTS
-
, (2012/12/14)
The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.
Composition for the treatment of damaged tissue
-
, (2008/06/13)
A pharmaceutical for use in damaged tissue, such as wound, treatment (e.g. healing) is described. The pharmaceutical comprising a composition which comprises: (a) a growth factor; and (b) an inhibitor agent; and optionally (c) a pharmaceutically acceptable carrier, diluent or excipient; wherein the inhibitor agent can inhibit the action of at least one specific adverse protein (e.g. a specific protease) that is upregulated in a damaged tissue, such as a wound, environment.