54708-14-4

Basic information

• Product Name: 2,6-DIMETHYLPHENYLACETONITRILE
• Synonyms: 2,6-DIMETHYLPHENYLACETONITRILE;2,6-Dimethylphenylacetonitrile,99%;2-(2,6-Dimethylphenyl)acetonitrile
• CAS NO: 54708-14-4
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• Mol File: 54708-14-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 31-33°C
• Boiling Point: 104°C 1mm
• Flash Point: 122.9 °C
• Appearance: /
• Density: 0.979 g/cm³
• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,6-DIMETHYLPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYLPHENYLACETONITRILE(54708-14-4)
• EPA Substance Registry System: 2,6-DIMETHYLPHENYLACETONITRILE(54708-14-4)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 54708-14-4(Hazardous Substances Data)

Usage

General Description

2,6-Dimethylphenylacetonitrile is a chemical compound consisting of a phenyl group with two methyl groups attached at the 2 and 6 positions, as well as an acetonitrile group. It is commonly used as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. This chemical is known for its use in the production of active pharmaceutical ingredients, as well as in the creation of herbicides and insecticides. Additionally, 2,6-Dimethylphenylacetonitrile is also used in the manufacturing of dyes and fragrances. Due to its versatile reactivity and functional group compatibility, this compound is valued for its role as an intermediate in the synthesis of diverse chemical products.

InChI:InChI=1/C10H11N/c1-8-4-3-5-9(2)10(8)6-7-11/h3-5H,6H2,1-2H3

Upstream product

• 18293-53-3 2-trimethylsilylacetonitrile 
• 576-22-7 2-Bromo-m-xylene 
• 632-46-2 2,6-dimethylbenzoic acid 
• 5402-60-8 2,6-dimethylbenzyl chloride 
• 143-33-9 sodium cyanide 
• 83902-02-7 2,6-dimethylbenzyl bromide 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1123-56-4 2,6-dimethylbenzaldehyde 
• 773837-37-9 sodium cyanide 
• 1071-36-9 sodium cyanoacetate 
• 608-28-6 2,6-dimethyliodobenzene 
• 87-62-7 2,6-dimethylaniline 
• 14920-81-1 methyl 2,6-dimethylbenzoate 
• 62285-58-9 2,6-dimethylbenzyl alcohol 

Downstream Products

• 76574-87-3 6-(2,6-Dimethyl-phenyl)-2-methyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 1026631-02-6 2-(2,6-Dimethyl-phenyl)-acetimidic acid ethyl ester 
• 1394973-42-2 benzo[d]thiazol-2-yl(2,6-dimethylphenyl)methanone 
• 185039-20-7 6-(2,6-dimethylphenyl)-7-imino-8-methyl-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamine 
• 92725-73-0 1-Diethylamino-3-(2,6-dimethyl-phenyl)-propanon-⁽²⁾ 
• 97021-64-2 1-Diaethylamino-3-<2,6-dimethyl-phenyl>-propan 
• 91552-37-3 1-Chlor-3-(2,6-dimethylphenyl)-propan-2-on 
• 69385-86-0 (2,6-dimethylphenyl)acetyl chloride 
• 94204-40-7 diethyl 2-(2,6-dimethylphenyl)malonate 
• 105337-15-3 ethyl 2-(2,6-dimethylphenyl)acetate 
• 179343-18-1 1-[2-amino-6-(2,6-dimethylphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea 
• 54707-85-6 2-(2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole 
• 344891-85-6 6-(2,6-dimethyl-phenyl)-2-methanesulfonyl-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 374064-82-1 2-(2,6-dimethyl-phenyl)-acetamidine 

Relevant articles and documents

PROCESS FOR PREPARING 2,6-DIALKYLPHENYLACETIC ACIDS

The invention relates to a multi-stage process for preparing 2,6-dialkylphenylacetic acids of the general formula (I) by reacting 2,6-dialkylbromobenzenes with (1) magnesium, (2) a formamide, (3) an acid, (4) hydrogenation of the benzaldehyde obtained, (5

MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

Mild palladium-catalyzed selective monoarylation of nitriles

Two new palladium-catalyzed procedures for the arylation of nitriles under less basic conditions than previously reported have been developed. The selective monoarylation of acetonitrile and primary nitriles has been achieved using α-silyl nitriles in the presence of ZnF2. This procedure is compatible with a variety of functional groups, including cyano, keto, nitro, and ester groups, on the aryl bromide. The arylation of secondary nitriles occurred in high yield by conducting reactions with zinc cyanoalkyl reagents. These reaction conditions tolerated base-sensitive functional groups, such as ketones and esters. The combination of these two methods, one with a-silyl nitriles and one with zinc cyanoalkyl reagents, provides a catalytic route to a variety of benzylic nitriles, which have not only biological significance but utility as synthetic intermediates. The utility of these new coupling reactions has been demonstrated by a synthesis of verapamil, a clinically used drug for the treatment of heart disease, by a three-step route from commercial materials that allows convenient variation of the aryl group.