54856-61-0

Basic information

• Product Name: 2-amino-5-chloronicotinaldehyde
• Synonyms: 2-amino-5-chloronicotinaldehyde;2-aMino-5-chloropyridine-3-carboxaldehyde;2-AMino-5-chloro-pyridine-3-carbaldehyde;2-Amino-5-chloropyridine-3-carboxaldehyde, 2-Amino-5-chloro-3-formylpyridine
• CAS NO: 54856-61-0
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Mol File: 54856-61-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 169-171°
• Boiling Point: 301.877 °C at 760 mmHg
• Flash Point: 136.371 °C
• Appearance: /
• Density: 1.442 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-amino-5-chloronicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-chloronicotinaldehyde(54856-61-0)
• EPA Substance Registry System: 2-amino-5-chloronicotinaldehyde(54856-61-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54856-61-0(Hazardous Substances Data)

Usage

Uses

2-Amino-5-chloronicotinaldehyde is an intermediate used to prepare benzopyrancarboxylates and quinolinecarboxylates as cyclooxygenase-2 inhibitors.

InChI:InChI=1/C6H5ClN2O/c7-5-1-4(3-10)6(8)9-2-5/h1-3H,(H2,8,9)

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 116026-94-9 2--3-pyridinecarboxaldehyde 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1441142-62-6 (2-amino-5-chloro-3-pyridyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol 

Relevant articles and documents

ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

HERBICIDAL COUMPOUNDS

The present invention relates to novel herbicidal [l,8]-naphthyridines of Formula (Ia) or (Ib), or an agronomically acceptable salt of said compound wherein R2, R3, R4, R5,R6,R7, R8, n, m, X and Q are as defined herein. The invention further relates to processes and intermediates for the preparation of the [l,8]-naphthyridines, to compositions which comprise the herbicidal compounds, and to their use for controlling weeds, in particular in crops of useful plants.

Substituted benzopyran analogs for the treatment of inflammation

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.