55114-48-2

Basic information

• Product Name: Imidazo[2,1-b]thiazole, 5,6-dihydro-3-methyl-
• Synonyms: 3-Methyl-5-phenyl-pent-1-in-3-ol;3-methyl-5,6-dihydroimidazo[2,1-b]thiazole;3-Methyl-5,6-dihydro-imidazo[2,1-b]thiazol;3-Methyl-2,3-b-dihydro-imidazothiazol
• CAS NO: 55114-48-2
• Molecular Formula: C6H8N2S
• Molecular Weight: 140.209
• Mol File: 55114-48-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231.3±23.0 °C(Predicted)
• Density: 1.38±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Imidazo[2,1-b]thiazole, 5,6-dihydro-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[2,1-b]thiazole, 5,6-dihydro-3-methyl-(55114-48-2)
• EPA Substance Registry System: Imidazo[2,1-b]thiazole, 5,6-dihydro-3-methyl-(55114-48-2)

Safety Data

• Hazardous Substances Data: 55114-48-2(Hazardous Substances Data)

Upstream product

• 96-45-7 N,N'-ethylenethiourea 
• 78-95-5 chloroacetone 
• 96-45-7 4,5-dihydro-1H-imidazole-2-thiol 
• 75697-82-4 7-(4-chlorobenzenesulphonyl)-3-methyl-5,6-dihydroimidazolo<2,1-b>thiazolium chloride 

Downstream Products

• 139313-12-5 3-methyl-7-<2-(4'-bromophenyl)-2-oxoethyl>-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 139313-11-4 3-methyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 139313-13-6 3-methyl-7-(2-ethoxy-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 75697-87-9 7-(4-Chloro-benzoyl)-3-methyl-5,6-dihydro-imidazo[2,1-b]thiazol-7-ium; chloride 

Relevant articles and documents

THIAZOLINE DERIVATIVE AND USE OF THE SAME

A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R5)-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or -N(R6)-; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

7-Alkylation and 7-Sulphonylation of 5,6-Dihydroimidazolo-thiazoles

Reinvestigation of the alkylation of 3-phenyl-5,6-dihydroimidazolothiazole has shown that methylation occurs exclusively at the 7-position, and that the free base is readily solvolysed to a mixture of 1-methylimidazolidin-2-one, 1-methylimidazolidine-2-thione, and diphenacyl sulphide and disulphide. 3-Methyl-5,6-dihydroimidazolothiazole with methane- and arene-sulphonyl chlorides gave the corresponding 7-sulphonylthiazolium chlorides.On heating, these rearranged to 3-(2-chloroethyl)-4-methyl-3-aryl (or alkyl)sulphonylimido-2,3-dihydrothiazoles.The 7-(4-chlorophenylsulphonyl) derivative lost this substituent with aqueous base while concentrated aqueous ammonia attacked the 7a-position leading to a 3--2-imino-4-methyl-2,3-dihydrothiazole.