55514-49-3Relevant articles and documents
Twelve-Step Asymmetric Synthesis of (-)-Nodulisporic Acid C
Godfrey, Nicole A.,Schatz, Devon J.,Pronin, Sergey V.
, p. 12770 - 12774 (2018)
A short, enantioselective synthesis of (-)-nodulisporic acid C is described. The route features two highly diastereoselective polycyclizations en route to the terpenoid core and the indenopyran fragment and a highly convergent assembly of a challenging indole moiety. Application of this chemistry allows for a 12-step synthesis of the target indoloterpenoid from commercially available material.
Asymmetric synthesis of α,β-substituted γ-amino acids via conjugate addition
Sabala, Rocío,Assad, Salomon,Mendoza, ángel,Jiménez, Jacqueline,Sansinenea, Estibaliz,Ortiz, Aurelio
, p. 1741 - 1744 (2019/06/05)
The first conjugate addition reaction of organocuprates to N-enoyl oxazolidinone where a N-protected γ-nitrogen atom and an α-methyl group are present into α, β-unsaturated system is described. This reaction gave anti-products in moderate yields and high diastereomeric ratios. The anti-products have two contiguous stereogenic centers, one formed by the conjugate addition reaction and the other by a diastereoselective protonation reaction. The removal of chiral oxazolidinone moiety and N-deprotection of amino group furnished chiral α, β-disubstituted γ-amino acids.
Total synthesis of AMF-26, an antitumor agent for inhibition of the golgi system, targeting adp-ribosylation factor 1
Shiina, Isamu,Umezaki, Yuma,Ohashi, Yoshimi,Yamazaki, Yuta,Dan, Shingo,Yamori, Takao
, p. 150 - 159 (2013/02/23)
An effective method for the total synthesis of 1 (AMF-26), a potentially promising new anticancer drug that disrupts the Golgi system by inhibiting the ADP-ribosylation factor 1 (Arf1) activation, has been developed for the first time. The construction of
