557756-85-1 Usage
Description
FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID, also known as Fmoc-N-amido-PEG4-acid, is a chemical compound that features a PEG (polyethylene glycol) linker with an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer enhances solubility in aqueous media, while the Fmoc group can be deprotected under basic conditions to reveal the free amine for further conjugations. The terminal carboxylic acid is capable of reacting with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable amide bond. FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID is characterized by its yellow oil appearance and is utilized in various applications across different industries.
Uses
Used in Bioconjugation:
FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a bioconjugation agent for the formation of stable amide bonds between primary amine groups and the terminal carboxylic acid. This application is particularly useful in the synthesis of bioactive molecules, drug conjugates, and the development of targeted drug delivery systems.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a key intermediate for the synthesis of various drug molecules. FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID's ability to form stable amide bonds and its solubility-enhancing PEG spacer make it a valuable component in the development of new therapeutic agents.
Used in Chemical Synthesis:
FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID is utilized as a versatile building block in chemical synthesis, particularly for the creation of complex molecular structures. FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID's reactivity and functional groups allow for a wide range of synthetic applications, including the development of novel materials and the modification of existing compounds.
Used in Research and Development:
In research and development, FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID serves as an important tool for studying the properties and behavior of various biomolecules. FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID's ability to form stable amide bonds and its compatibility with aqueous media make it a valuable asset in the exploration of new chemical reactions and the development of innovative research methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 557756-85-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,7,7,5 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 557756-85:
(8*5)+(7*5)+(6*7)+(5*7)+(4*5)+(3*6)+(2*8)+(1*5)=211
211 % 10 = 1
So 557756-85-1 is a valid CAS Registry Number.
557756-85-1Relevant articles and documents
Complexation of Polyethyleneglycol Containing Small Molecules with Magnesium Chloride as a Purification and Isolation Strategy
Eastgate, Martin D.,Li, Jun,Pathirana, Charles,Qiu, Shenjie,Schmidt, Michael A.,Zheng, Bin
, p. 2270 - 2276 (2021/09/28)
Polyethyleneglycol (PEG) containing compounds are often non-crystalline, gel-like oils, which pose great challenges for handling, purification, and isolation, particularly on large scales. To overcome these isolation challenges, a new procedure has been established, which is based on the discovery that complexation with magnesium chloride (MgCl2) can transform these oily intermediates into solid complexes. This method significantly improves the handling of PEG compounds and leads a more process-friendly isolation for larger scale handling. Often, the resulting PEG-MgCl2 complexes could be used directly in subsequent transformations, such as a peptide coupling. Alternately, the inorganic Mg salt used in these weakly bonded complexes can be readily dissociated and removed from the desired PEG derivatives.
Polypeptide, protein PEG modifier synthesis method
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Paragraph 0019; 0027; 0031, (2017/09/26)
The present invention discloses a synthesis route and an operation method of a peptide and protein pegylation agent, wherein the pegylation agent is used for polypeptides and drug structure modification, the raw materials of the method are cheap, and the amount of the polyethylene glycol can be defined.
