56072-16-3Relevant articles and documents
Ready Access to Densely Substituted Furans Using Tsuji-Wacker-Type Cyclization
Masal, Dattatraya P.,Choudhury, Rahul,Singh, Aman,Reddy, D. Srinivasa
, p. 556 - 568 (2022/01/14)
A competent method for the construction of highly substituted furans catalyzed by Pd(II) and Cu(II) chloride has been developed. The method provides easy access to di-, tri-, and tetrasubstituted furans from corresponding diols with relatively mild condit
Zinc-Mediated Efficient and Selective Reduction of Carbonyl Compounds
Mandal, Tirtha,Jana, Snehasish,Dash, Jyotirmayee
, p. 4972 - 4983 (2017/09/13)
We herein describe for the first time that an optimized combination of Zn and NH4Cl can be used for the selective reduction of aldehydes and ketones to the corresponding alcohols. The aldehyde and keto groups are selectively reduced in the presence of azide, cyano, epoxy, ester, and carbon–carbon double-bond functional groups. A broad functional-group compatibility, chemoselective reduction of aldehydes in the presence of ketones, and selective reduction of isatins at the C3 carbonyl group are the highlights of the present method.
2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents
Singh, Palwinder,Mittal, Anu,Kaur, Satwinderjeet,Holzer, Wolfgang,Kumar, Subodh
scheme or table, p. 2706 - 2712 (2009/02/03)
2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofuran-3-ols were designed and synthesized by the allylations of benzoins followed by iodocyclization and nucleophilic replacement reactions with ethanthiol. These molecules exhibit IC50 for COX-2 at 50 over all the 59 human tumor cell lines at μ M concentration. The Royal Society of Chemistry.
