5650-44-2

Basic information

• Product Name: 2-(methylamino)propiophenone
• Synonyms: 2-(methylamino)propiophenone;2-Methylamino-1-phenylpropan-one;monomethylpropion;2-methylamino-1-phenyl-propan-1-one;Methcathinone;LPLLVINFLBSFRP-UHFFFAOYSA-N
• CAS NO: 5650-44-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: 227-092-7
• Mol File: 5650-44-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 182-184 °C
• Boiling Point: 281.8 °C at 760 mmHg
• Flash Point: 118.2 °C
• Appearance: /
• Density: 1.04 g/cm³
• Vapor Pressure: 0.00349mmHg at 25°C
• Refractive Index: 1.557
• PKA: 7.14±0.10(Predicted)
• CAS DataBase Reference: 2-(methylamino)propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylamino)propiophenone(5650-44-2)
• EPA Substance Registry System: 2-(methylamino)propiophenone(5650-44-2)

Safety Data

• Hazardous Substances Data: 5650-44-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13NO/c1-3-10(12)8-6-4-5-7-9(8)11-2/h4-7,11H,3H2,1-2H3

Upstream product

• 16735-30-1 2-(N-benzyl-N-methylamino)-1-phenylpropan-1-one 
• 100-52-7 benzaldehyde 
• 90-82-4 pseudoephedrine 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 
• 74-89-5 methylamine 
• 71-43-2 benzene 
• 299-42-3 ephedrine 
• 100791-85-3 (4S,5S)-2-[(R)-1-bromoethyl]-2-phenyl-1,3-dioxoethane-4,5-dicarboxylate 
• 100791-77-3 (4S,5S)-2-Ethyl-2-phenyl-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester 
• 93-55-0 1-phenyl-propan-1-one 
• 5650-44-2 methcathinone 
• 126192-86-7 (1S,2S)-(2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamic acid tert-butyl ester 
• 389131-81-1 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-propanone 
• 90-82-4 rac-pseudoephedrine 

Downstream Products

• 101872-43-9 2-heptyl-1,5-dimethyl-4-phenyl-2,5-dihydro-1H-imidazole 
• 537-46-2 Methamphetamin 
• 299-42-3 ephedrine 
• 52340-16-6 (1R,2S)-1-cyclohexyl-2-methylamino-propan-1-ol 
• 5650-44-2 (-)-Methcathinone 
• 160977-88-8 (+)-Methcathinone 
• 124136-46-5 (1R,2S)-1-phenyl-1-methyl-2-methylamino-1-propanol hydrochloride 
• 321-97-1 (1R,2R)-pseudoephedrine 
• 321-98-2 (1S,2R)-(+)-ephedrine 
• 1201-56-5 (+/-)-N-methylephedrine 
• 25394-33-6 (2-chloro-1-methyl-2-phenyl-ethyl)-methyl-amine 
• 7632-10-2 methamphetamin 
• 299-42-3 2-methylamino-1-phenylpropanol 
• 90-82-4 rac-pseudoephedrine 

Relevant articles and documents

Preparation of (S)-(-)-alpha-methylamino propiophenone

The invention relates to the field of chemistry, in particular to preparation of (S)-(-)-alpha-methylamino propiophenone. The preparation comprises the following steps: reacting (+/-)-alpha-methylamino propiophenone and (2R, 3R)-(-)-tartaric acid derivative in a solvent added with alcohol ether to form salt, crystallizing and filtering to obtain (S)-(-)-alpha-methylamino propiophenone (2R, 3R)-(-)-tartaric acid derivative salt, acidifying, alkalizing, and extracting with a solvent, and distilling to remove the solvent to obtain the product (S)-(-)-alpha-methylamino propiophenone.

Nanorods of FeVO4: An efficient heterogeneous catalyst for chemoselective oxidation of benzylic alcohols

Controllable fabrication of iron vanadate (FeVO4) was achieved by the hydrothermal approach. The excellent catalytic activity of the prepared nanorods of iron vanadate for the oxidation of benzylic alcohols as well as its potential for oxidation of the benzylic sp3 C-Hs in the presence of urea hydrogen peroxide (UHP) as oxidant was reported. The prepared nanorods and nanospheres were fully characterized by FT-IR, XRD, EDAX, ICP-AES, SEM, and TEM. In the presence of the catalyst, alcohols chemoselectively (100%) convert to the corresponding aldehydes/ketones, giving a total turnover number about 380 for 10 consecutive runs.

Preparation methods for ephedrine or pseudoephedrine and for ephedrine or pseudoephedrine intermediate

The invention discloses a preparation method for an ephedrine or pseudoephedrine intermediate. The preparation method comprises the following steps: with 2-chloropropionyl chloride and benzene as starting materials, carrying out the Friedel-Crafts reaction under the catalysis of Lewis acid so as to produce 2-chloro-1-phenyl-1-acetone; and reacting produced 2-chloro-1-phenyl-1-acetone with methylamine in an aprotic solvent so as to produce 2-methylamino-1-phenyl-1-acetone. The invention also discloses a preparation method for ephedrine or pseudoephedrine. According to the methods, phosphorus trichloride with severe pollution is not used anymore, and dangerous and expensive bromine is not used any longer; the Friedel-Crafts reaction and methylamination are carried out in the same solvent, so cost for public works is saved; and a safe, simple, cheap, green and novel process is provided for synthesis of ephedrine and pseudoephedrine.