57049-58-8

Basic information

• Product Name: Benzofuran, 2,3-dihydro-3-phenyl-
• CAS NO: 57049-58-8
• Molecular Formula: C14H12O
• Molecular Weight: 196.249
• Mol File: 57049-58-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzofuran, 2,3-dihydro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2,3-dihydro-3-phenyl-(57049-58-8)
• EPA Substance Registry System: Benzofuran, 2,3-dihydro-3-phenyl-(57049-58-8)

Safety Data

• Hazardous Substances Data: 57049-58-8(Hazardous Substances Data)

Upstream product

• 117-99-7 2-Hydroxybenzophenone 
• 100-58-3 phenylmagnesium bromide 
• 90-02-8 salicylaldehyde 
• 1422447-26-4 2-(α-phenyl-p-toluenesulfonyl)phenol 
• 1774-47-6 trimethylsulfoxonium iodide 
• 40473-50-5 2-(hydroxy(phenyl)methyl)phenol 
• 71104-25-1 2-methoxybenzophenone hydrazone 
• 2553-04-0 ortho-methoxybenzophenone 
• 96-09-3 styrene oxide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 83922-77-4 2-methoxyphenyl(phenyl)diazomethane 
• 110-82-7 cyclohexane 
• 67-56-1 methanol 

Downstream Products

• 39477-86-6 1-phenyl-1-(2-hydroxyphenyl)ethene 
• 25173-82-4 (2-hydroxy-phenyl)-phenyl-acetic acid 
• 64-19-7 acetic acid 
• 108-95-2 phenol 
• 29909-72-6 3-Phenylbenzofuran 
• 111864-84-7 trans-2-methoxy-3-phenyl-2,3-dihydrobenzofuran 
• 111864-84-7 cis-2-methoxy-3-phenyl-2,3-dihydrobenzofuran 

Relevant articles and documents

A mild method for generation of o-quinone methides under basic conditions. the facile synthesis of trans-2,3-dihydrobenzofurans

A novel and efficient method for the generation of o-quinone methide intermediates was developed from the readily available 2-tosylalkylphenols under the mild basic conditions, and their reactions with sulfur ylides were investigated for the stereoselective synthesis of trans-2,3-dihydrobenzofurans. The Royal Society of Chemistry 2013.

Generation and Reactions of 2-Alkoxydiphenylcarbenes in Fluid Solution and Rigid Matrices

Irradiation of 2-alkoxydiphenyldiazomethanes 1 in cyclohexane at room temperature produced 3-phenyldihydrobenzofurans 3 presumably as a result of intramolecular C-H insertion of 2-alkoxydiphenylcarbenes 2.Irradiation of compounds 1 in cyclohexane matrix at -196 deg C gave intermolecular C-H insertion products 4 at the expense of benzofurans 3.The formation of products 4 is explicable in terms of H-atom tunnelling to the triplet state of carbenes 2, followed by coupling of the resulting radical pairs.Product ratios 3:4 were somewhat sensitive to the bulk of the alkoxy group at the 2-position.This can be explained in terms of the matrix effect on the relative population of the rotational isomers of the carbene 2.Irradiation of compounds 1 in methanol at room temperature afforded O-H insertion products 5 almost exclusively, whereas irradiation in methanol matrix at -196 deg C gave C-H insertion products 6 along with other products 3 and 5.