5711-73-9

Basic information

• Product Name: 5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE
• Synonyms: 5-(3-Pyridyl)-1,3,4-oxadiazol-2-amine;4-oxadiazole,2-amino-5-(3-pyridyl)-3;5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE;3-(5-AMINO-1,3,4-OXADIAZOL-2-YL)PYRIDINE;5-pyridin-3-yl-1,3,4-oxadiazol-2-amine
• CAS NO: 5711-73-9
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.15
• Mol File: 5711-73-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 230-233°C
• Boiling Point: 375.1 °C at 760 mmHg
• Flash Point: 180.7 °C
• Appearance: /
• Density: 1.357 g/cm³
• Vapor Pressure: 7.96E-06mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.94±0.12(Predicted)
• CAS DataBase Reference: 5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE(5711-73-9)
• EPA Substance Registry System: 5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE(5711-73-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 5711-73-9(Hazardous Substances Data)

Usage

General Description

5-Pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is a chemical compound with the molecular formula C7H6N4O. It is an organic compound with a pyridine ring and an oxadiazole ring, and is commonly used in pharmaceutical research and development. It has potential applications in medicinal chemistry and drug discovery due to its ability to bind to certain biological targets, such as enzymes or receptors, and modulate their activity. Additionally, this compound may exhibit interesting pharmacological properties, making it a valuable tool for the study of biological systems and potential therapeutic agents. Overall, 5-pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is a versatile chemical with potential applications in various scientific and pharmaceutical fields.

InChI:InChI=1/C7H6N4O/c8-7-11-10-6(12-7)5-2-1-3-9-4-5/h1-4H,(H2,8,11)

Upstream product

• 13370-80-4 pyridine-3-carboxaldehyde semicarbazone 
• 500-22-1 3-pyridinecarboxaldehyde 
• 14397-23-0 nicotinoyl thiosemicarbazide 

Relevant articles and documents

Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Anti-bacterial Agents

Objective: The objective of the present study was to prepare the 5-substituted 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole derivatives and evaluate their potential anticancer, antibac-terial and antifungal activities. Methods: Twenty-seven derivatives were synthesized by iodine-mediated cyclization of semicarba-zones or thiosemicarbazones obtained from condensation of semicarbazide or thiosemicarbazide and aldehydes. The structures were confirmed by1H-NMR,13C-NMR and MS spectra. The antibacterial and antifungal activities were evaluated by diffusion method and the anticancer activities were evaluated by MTT assay. Results: Twenty-seven derivatives have been synthesized in moderate to good yields. A number of derivatives exhibited potential antibacterial, antifungal and anticancer activities. Conclusion: Compounds (1b, 1e and 1g) showed antibacterial activity against Streptococcus faecal-is, MSSA and MRSA with MIC value ranging between 4 to 64 μg/mL. Compound (2g) showed anti-fungal activity against Candida albicans (8 μg/mL) and Aspergillus niger (64 μg/mL). Compound (1o) exhibited high cytotoxic activity against HepG2 cell line (IC50 value 8.6 μM) which is compara-ble to the activity of paclitaxel, and is non-toxic on LLC-PK1 normal cell line. The structure activity relationship and molecular docking study of the synthesized compounds have also been reported.

2-amino-5-substituted 1,3,4-oxadiazoles and 5-imino-2-substituted delta-2-1,3,4-oxadiazolines. A group of novel muscle relaxants.

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