57135-09-8

Basic information

• Product Name: PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL
• Synonyms: PYRIDO[3,2-D]-1,3-THIAZOL-2-THIOL;PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL;PYRIDO[3,4-D]-1,3-THIAZOL-2-THIOL;THIAZOLO(5,4-B)PYRIDINE-2-THIOL;2-Mercaptothiazolo[5,4-b]pyridine;[1,3]Thiazolo[5,4-b]pyridine-2-thiol;Pyrido[3,2-d][1,3]thiazole-2-thiol, 2-Mercapto-[1,3]thiazolo[5,4-b]pyridine, 2-Sulphanyl-[1,3]thiazolo[5,4-b]pyridine;Thiazolo[5,4-b]pyridine-2(1H)-thione
• CAS NO: 57135-09-8
• Molecular Formula: C₆H₄N₂S₂
• Molecular Weight: 168.24
• Mol File: 57135-09-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: >300
• Boiling Point: 343.9 °C at 760 mmHg
• Flash Point: 161.8 °C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 6.85E-05mmHg at 25°C
• Refractive Index: 1.802
• PKA: 8.47±0.20(Predicted)
• CAS DataBase Reference: PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL(57135-09-8)
• EPA Substance Registry System: PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL(57135-09-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 57135-09-8(Hazardous Substances Data)

Usage

General Description

PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL is a chemical compound that consists of a pyrido-thiazole ring system with a thiol functional group attached at the second position. It is often used in a variety of pharmaceutical and industrial applications due to its unique structure and properties. PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL has been studied for its potential antioxidant, antimicrobial, and anti-inflammatory properties. It can also be used in the synthesis of various heterocyclic compounds and as a building block in organic chemistry. However, the compound should be handled with care, as it may be hazardous if not properly handled or stored.

InChI:InChI=1/C6H4N2S2/c9-6-8-4-2-1-3-7-5(4)10-6/h1-3H,(H,8,9)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 140-89-6 potassium ethyl xanthogenate 
• 39856-58-1 3-amino-2-bromopyridine 
• 75-15-0 carbon disulfide 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 7783-06-4 hydrogen sulfide 
• 7732-18-5 water 
• 38240-21-0 2-mercapto-3-amino pyridine 

Downstream Products

• 67219-23-2 2-(2-methyl-propane-1-sulfonyl)-thiazolo[5,4-b]pyridine 
• 67219-22-1 2-benzylsulfanyl-thiazolo[5,4-b]pyridine 
• 67219-36-7 2-(3-chloro-benzylsulfanyl)-thiazolo[5,4-b]pyridine 
• 57135-10-1 2-(methylthio)thiazolo[5,4-b]pyridine 
• 215667-08-6 2-Benzhydrylsulfanyl-thiazolo[5,4-b]pyridine 
• 65128-67-8 2-(methylthio)thiazolo[4,5-c]pyridine 
• 405198-51-8 2-(methylthio)thiazolo[5,4-c]pyridine 
• 99158-60-8 2-(methylthio)[1,3]thiazolo[4,5-b]pyridine 
• 67219-24-3 2-phenylmethanesulfonyl-thiazolo[5,4-b]pyridine 
• 67219-25-4 2-[(3-chloro-phenyl)-methanesulfonyl]-thiazolo[5,4-b]pyridine 
• 67219-26-5 2-[(3-trifluoromethyl-phenyl)-methanesulfonyl]-thiazolo[5,4-b]pyridine 
• 67219-28-7 2-(4-methyl-piperazin-1-yl)-thiazolo[5,4-b]pyridine 
• 213684-77-6 6-(thiazolo[5,4-b]pyridin-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide 

Relevant articles and documents

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Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof

The present invention provides compounds that can enhance functional O-mannosylation of proteins including alpha-dystroglycan. Also provided are methods of preparation of the compounds defined by the formula I. Also provided are the methods of using the compounds or the pharmaceutical acceptable salts or prodrugs thereof in treating and preventing subjects suffering from the diseases including muscular dystrophies and cancers.

General Entry into o-,o′-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

A general redox-neutral approach into the o-,o′-heteroatom-linked N-(hetero)aryl-imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl)-pyridinium-N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores. (Figure presented.).

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.