99158-60-8

Basic information

• Product Name: Thiazolo[4,5-b]pyridine, 2-(Methylthio)-
• Synonyms: Thiazolo[4,5-b]pyridine, 2-(Methylthio)-;2-methylsulfanyl-[1,3]thiazolo[4,5-b]pyridine
• CAS NO: 99158-60-8
• Molecular Formula: C₇H₆N₂S₂
• Molecular Weight: 182.26594
• Mol File: 99158-60-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 74-76 °C(Solv: hexane (110-54-3))
• Boiling Point: 317.1±34.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 0.12±0.50(Predicted)
• CAS DataBase Reference: Thiazolo[4,5-b]pyridine, 2-(Methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[4,5-b]pyridine, 2-(Methylthio)-(99158-60-8)
• EPA Substance Registry System: Thiazolo[4,5-b]pyridine, 2-(Methylthio)-(99158-60-8)

Safety Data

• Hazardous Substances Data: 99158-60-8(Hazardous Substances Data)

Usage

Description

Thiazolo[4,5-b]pyridine, 2-(methylthio)is a chemical compound with the molecular formula C8H7NS. It is a thiazole derivative that contains a pyridine ring and a methylthio group. Its unique chemical structure and properties make it a valuable building block for the design and synthesis of potential drug candidates with therapeutic potential in the treatment of various diseases and conditions.

Uses

Used in Pharmaceutical Research and Drug Development:
Thiazolo[4,5-b]pyridine, 2-(methylthio)is used as a small molecule inhibitor in the synthesis of potential drug candidates for various biological targets. Its unique chemical structure and properties make it a valuable building block in the development of new therapeutic agents.
Used in Organic Chemistry and Chemical Synthesis:
Thiazolo[4,5-b]pyridine, 2-(methylthio)is of interest in the study of organic chemistry and chemical synthesis, providing insights into the properties and reactivity of thiazole derivatives and their potential applications in the development of new chemical compounds and materials.

Upstream product

• 57135-09-8 1H,2H-[1,3]thiazolo[5,4-b]pyridine-2-thione 
• 74-88-4 methyl iodide 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 99158-61-9 thiazolo[4,5-b]pyridine-2(3H)-thione 
• 99158-61-9 2-mercaptothiazolo[4,5-b]pyridine 

Relevant articles and documents

Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine

Proteome profiling by activated esters identified >9000 ligandable lysines but they are limited as covalent inhibitors due to poor hydrolytic stability. Here we report our efforts to design and discover a new series of tunable amine-reactive electrophiles (TAREs) for selective and robust labeling of lysine. The major challenges in developing selective probes for lysine are the high nucleophilicity of cysteines and poor hydrolytic stability. Our work circumvents these challenges by a unique design of the TAREs that form stable adducts with lysine and on reaction with cysteine generate another reactive electrophiles for lysine. We highlight that TAREs exhibit substantially high hydrolytic stability as compared to the activated esters and are non-cytotoxic thus have the potential to act as covalent ligands. We applied these alternative TAREs for the intracellular labeling of proteins in different cell lines, and for the selective identification of lysines in the human proteome on a global scale.

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.