57204-65-6

Basic information

• Product Name: 5-PHENYL-1H-PYRAZOLE-3-CARBALDEHYDE
• Synonyms: 5-PHENYL-1H-PYRAZOLE-3-CARBALDEHYDE
• CAS NO: 57204-65-6
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18332
• Mol File: 57204-65-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 420.4 °C at 760 mmHg
• Flash Point: 209.6 °C
• Appearance: /
• Density: 1.248g/cm³
• Storage Temp.: 2-8°C
• PKA: 10.72±0.10(Predicted)
• CAS DataBase Reference: 5-PHENYL-1H-PYRAZOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-1H-PYRAZOLE-3-CARBALDEHYDE(57204-65-6)
• EPA Substance Registry System: 5-PHENYL-1H-PYRAZOLE-3-CARBALDEHYDE(57204-65-6)

Safety Data

• Hazardous Substances Data: 57204-65-6(Hazardous Substances Data)

Usage

General Description

5-Phenyl-1h-pyrazole-3-carbaldehyde is a chemical compound with the molecular formula C10H8N2O. It is a yellow to light brown solid that is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. 5-Phenyl-1h-pyrazole-3-carbaldehyde is an aldehyde, meaning it contains a carbonyl group attached to a phenyl ring and a pyrazole ring. 5-Phenyl-1h-pyrazole-3-carbaldehyde has been studied for its potential biological activities, such as its ability to inhibit certain enzymes and its potential as an anti-inflammatory agent. It is important to handle this chemical with care, as it may pose hazards to health and the environment.

Upstream product

• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 98-86-2 acetophenone 
• 56426-35-8 methyl 5-phenyl-1H-pyrazole-3-carboxylate 
• 179057-19-3 (5-phenyl-1H-pyrazol-3-yl)methanol 
• 179057-19-3 (3-phenyl-1H-pyrazol-5-yl)methanol 
• 536-74-3 phenylacetylene 
• 107805-11-8 5-Dimethoxymethyl-3-phenyl-1H-pyrazole 

Downstream Products

• 1137165-32-2 ethyl 6-methyl-2-phenylpyrazolo[1,5-a]pyridine-5-carboxylate 
• 1137165-29-7 ethyl (Z)-3-chloro-4-(5-formyl-3-phenyl-1H-pyrazol-1-yl)but-2-enoate 
• 1448604-40-7 diethyl 2-phenylpyrazolo[1,5-a]pyridin-5-ylphosphonate 

Relevant articles and documents

Synthesis of nitrogen bridgehead heterocycles with phosphonates via a novel tandem process

A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-1- enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: SN2, deprotonation followed by electron flow, nucleophic additon and elimination of water.

Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas

A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.