5728-33-6

Basic information

• Product Name: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: 4-(3-METHYLPHENYL)BENZOIC ACID;3'-METHYLBIPHENYL-4-CARBOXYLIC ACID;3'-METHYL [1,1'-BIPHENYL]-4-CARBOXYLIC ACID;AKOS BAR-0004;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-METHYL-;CHEMBRDG-BB 4400412;RARECHEM AL BE 1342;4-(3-Tolyl)benzoic acid
• CAS NO: 5728-33-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 5728-33-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 375.7°Cat760mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.156
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(5728-33-6)
• EPA Substance Registry System: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(5728-33-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5728-33-6(Hazardous Substances Data)

Usage

Uses

It is used as an active pharmaceutical intermediate.

Upstream product

• 7383-90-6 3,4'-dimethylbiphenyl 
• 93-58-3 benzoic acid methyl ester 
• 108-44-1 1-amino-3-methylbenzene 
• 591-17-3 meta-bromotoluene 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 350792-94-8 (cyclohexyl)(difluoro)(3-methylphenyl)silane 
• 586-76-5 4-Bromobenzoic acid 
• 17933-03-8 m-tolylboronic acid 
• 619-58-9 4-iodobenzoic acid 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 350792-86-8 (dichloro)(cyclohexyl)(3-methylphenyl)silane 
• 134694-63-6 ethyl 3'-methyl-[1,1'-biphenyl]-4-carboxylate 
• 89900-94-7 methyl 3'-methyl-[1,1'-biphenyl]-4-carboxylate 

Downstream Products

• 473717-55-4 (10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-(3'-methyl-[1,1'-biphenyl]-4-yl)-methanone 

Relevant articles and documents

A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of RXRs holds high potential but available RXR activators suffer from limited safety. Selectivity for RXR subtypes or for certain RXR heterodimers are promising strategies for safer RXR modulation. Here, we report systematic structure-activity relationship studies on biphenyl carboxylates as new RXR ligand chemotype. We discovered specific structural modifications that enhance potency on RXRs, govern subtype preference, and vary modulation of different RXR heterodimers. Fusion of these structural motifs enabled specific tuning of subtype preferential profiles with markedly improved potency. Our results provide further evidence that RXR subtype selective ligands can be designed and present a novel chemotype of RXR modulators that can be tuned for subtype and heterodimer preferences.

CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

An improved protocol for ligandless Suzuki-Miyaura coupling in water

Using a reverse order of addition of reagents, PdCl2 and Pd(OAc)2 are efficient catalysts for the Suzuki-Miyaura reactions in water. The ligandless and mild conditions, the high stability of the catalytic system, short reaction time and good to excellent yields are important features of this protocol.