574-16-3Relevant articles and documents
Imidazole oxime ester compound, preparation method, composition and use thereof (by machine translation)
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Paragraph 0039-0042, (2019/05/11)
The invention relates to novel imidazole oxime ester compound, preparation method, composition and in photoinitiators, photosensitizers, the light absorbent, or sensitizers of the application. The invention imidazole oxime ester compound, at the same time with imidazole kind of light initiator (for example BCIM) and oxime mere initiator (for example 0 XE - 1) structural features. In one aspect, the compounds of the invention has improved the imidazole kind of light will produce sludge to the shortcoming of the initiator. On the other hand, compound of the present invention improved the thermal stability of the oxime [...] initiator problem not good, and increasing the operating convenience. (by machine translation)
Discovery of a series of ruthenium(II) derivatives with α-dicarbonylmonoxime as novel inhibitors of cancer cells invasion and metastasis
He, Yihui,Xue, Huiying,Zhang, Wendian,Wang, Li,Xiang, Guangya,Li, Lei,Shang, Xianmei
, p. 82 - 92 (2017/05/19)
A series of novel ruthenium(II)-cymene complexes (1–9) with substituted α-dicarbonylmonoximes of general formula [Ru(η6-cymene)(L)Cl] (L?=?N,O-chelating bidentate α-dicarbonylmonoxime derivatives) have been synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR spectroscopies, and in three cases by single crystal X-ray diffraction analysis. The most effective compound 9 displays remarkable anti-invasion and anti-metastasis properties without apparent cytotoxicity toward three different human cancer cell lines (MCF-7, Hela and HepG2). Further protein level studies suggest that the anti-metastasis activity of the complexes may result from the increasing expression of E-cadherin and reducing expression of Vimentin.
Optically active imidazoles derived from enantiomerically pure trans-1,2-diaminocyclohexane
Mloston, Grzegorz,Rygielska, Dorota,Jasinski, Marcin,Heimgartner, Heinz
body text, p. 669 - 674 (2011/07/08)
A new exploration of monoprotected derivatives of trans-1,2- diaminocyclohexane as a platform for the synthesis of enantiomerically pure imidazole derivatives is described. The primary amino group (-NH2), present in the mono-imine derivative of salicylic aldehyde (hemi-salen derivative) 5 was used for sequential reactions with formaldehyde and the corresponding α-(hydroxyimino)ketone. (S)-(-)-1-Phenylethylamine was also used as starting material for the preparation of new imidazole N-oxides 7c and 10a-c, bearing a chiral N-(1-phenylethyl)carboxamido function at C(4). Imidazole N-oxides 10a,b possessing either a Me or i-Pr group at N(1), respectively, follow the known sulfur-transfer pathway to afford the corresponding imidazole-2-thiones 13a,b. However, in the case of imidazole N-oxide 10c with a bulky adamantan-1-yl substituent at N(1), the attempted 'sulfur-transfer reaction' led to the deoxygenated imidazole derivative 14. Finally, the same reaction with 7c, which bears an electron-withdrawing N-(1-phenylethyl) carboxamide residue at C(4) of the imidazole ring, yielded a mixture of deoxygenated imidazole 16 and imidazole-2-thione 15c.
