57479-13-7

Basic information

• Product Name: 8-(4-methylphenyl)-quinoline
• Synonyms: 8-(4-methylphenyl)-quinoline
• CAS NO: 57479-13-7
• Molecular Weight: 219.286
• Mol File: 57479-13-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 8-(4-methylphenyl)-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-methylphenyl)-quinoline(57479-13-7)
• EPA Substance Registry System: 8-(4-methylphenyl)-quinoline(57479-13-7)

Safety Data

• Hazardous Substances Data: 57479-13-7(Hazardous Substances Data)

Upstream product

• 916314-51-7 quinolin-8-yl methanesulfonate 
• 5720-05-8 4-methylphenylboronic acid 
• 10522-42-6 toluene-4-sulfonic acid quinolin-8-yl ester 
• 91-22-5 quinoline 
• 106-38-7 para-bromotoluene 
• 16567-18-3 8-bromoquinoline 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 90252-89-4 p-tolylzinc(II) chloride 
• 938-33-0 8-methoxyquinoline 
• 380481-66-3 5,5-dimethyl-2-(4-methylphenyl)-1,3,2-dioxaborinane 
• 86-58-8 8-quinolinylboronic acid 
• 1038-95-5 Tri(p-tolyl)phosphine 
• 1613-37-2 Quinoline N-oxide 
• 2403-51-2 2-(4-methylphenyl)-1,3-dioxolane 

Relevant articles and documents

Palladium-catalyzed Suzuki-Miyaura coupling of aryl sulfamates with arylboronic acids

Readily available NHC-Pd(ii)-Mp complexes 2 showed efficient catalytic activity toward the Suzuki-Miyaura coupling of aryl sulfamates with arylboronic acids or potassium phenyltrifluoroborate, giving the expected coupling products in good to high yields.

Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines

We report a convenient method for the highly site-selective borylation of 8-arylquinoline. The reaction proceeds smoothly in the presence of a catalytic amount of [Ir(OMe)(cod)] 2and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing a series of borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed into various important synthons by using known transformations.

Preparation method of para-substituted aryl compound

The invention discloses a preparation method of a para-substituted aryl compound shown as a formula (I) which is described in the specfication. The preparation method is characterized by comprising the following step of: subjecting an aryl sulfonium salt shown as a formula (II) which is described in the specfication and boride to a coupling reaction in a solvent in an inert atmosphere under the action of alkali and a palladium catalyst to obtain the para-substituted aryl compound. According to the method, mono-substituted aromatic hydrocarbon is taken as a substrate, the aryl sulfonium salt isconstructed in situ, and the palladium catalyst catalyzes the aryl sulfonium salt constructed in situ to undergo the Suzuki-Miyaura coupling reaction, so a mono-substituted aromatic hydrocarbon para-arylation or alkenylation product is constructed quickly and efficiently. The method is mild in conditions, high in substrate universality and wide in tolerance of a heterocyclic coupling substrate.