57536-38-6

Basic information

• Product Name: 2-(phenylthio)-5-methoxybenzoic acid
• Synonyms: 2-(phenylthio)-5-methoxybenzoic acid
• CAS NO: 57536-38-6
• Molecular Weight: 260.313
• Mol File: 57536-38-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(phenylthio)-5-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(phenylthio)-5-methoxybenzoic acid(57536-38-6)
• EPA Substance Registry System: 2-(phenylthio)-5-methoxybenzoic acid(57536-38-6)

Safety Data

• Hazardous Substances Data: 57536-38-6(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 586-38-9 3-Methoxybenzoic acid 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 57536-70-6 (5-Methoxy-2-phenylsulfanyl-phenyl)-acetonitrile 
• 57536-71-7 (5-Methoxy-2-phenylsulfanyl-phenyl)-acetic acid 

Relevant articles and documents

Ruthenium(II)-Catalyzed ortho-C-H Chalcogenation of Benzoic Acids via Weak O-Coordination: Synthesis of Chalcogenoxanthones

A general protocol for direct chalcogenation of inert C-H bonds of (hetero)aromatic carboxylic acids is developed with a ruthenium(II) catalyst using readily available starting materials, offering densely substituted ortho-chalcogenyl aromatic acids in high yields (up to 96%). The strategy avoids the installation of an external directing group, use of metallic oxidants, and features operational simplicity with ample substrate scope. Synthetic application en route to biologically important chalcogenoxanthones is also demonstrated. This work represents the first example of ruthenium(II)-catalyzed direct C-H chalcogenation of benzoic acids.

Potential antipsychotics: 2 methoxy, 2 methylthio, 2 (dimethylsulfamoyl) and 2 trifluoromethyl 10 piperazinodibenzo[b,f]thiepins

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