57699-28-2

Basic information

• Product Name: Methyl 2-(4-broMophenyl)-2-oxoacetate
• Synonyms: Methyl 2-(4-broMophenyl)-2-oxoacetate;4-Bromo-oxo-benzeneacetic acid methyl ester
• CAS NO: 57699-28-2
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05408
• EINECS: -0
• Mol File: 57699-28-2.mol
• Article Data: 36

Chemical Properties

• Melting Point: 49-51 °C
• Boiling Point: 308.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.546±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-(4-broMophenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-broMophenyl)-2-oxoacetate(57699-28-2)
• EPA Substance Registry System: Methyl 2-(4-broMophenyl)-2-oxoacetate(57699-28-2)

Safety Data

• Hazardous Substances Data: 57699-28-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-(4-bromophenyl)-2-oxoacetate is a synthetic, organic chemical compound characterized by the presence of a bromophenyl group. Its molecular formula is C9H7BrO3. Methyl 2-(4-broMophenyl)-2-oxoacetate exhibits exact mass and monoisotopic mass of 245.979034 g/mol and 245.978294 g/mol respectively. It falls under the category of bromobenzenes and is chiefly used in the realm of chemical research. Being a bromine compound, it also models characteristics of halogenated hydrocarbons which present unique reactivity associated with halogens. The detailed properties and further potential uses of this compound are subject to ongoing scientific research.

Upstream product

• 67-56-1 methanol 
• 5195-29-9 4-bromophenylglyoxal 
• 586-75-4 4-chlorobenzoyl chloride 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 75748-11-7 (4-bromophenyl)(trimethylsilyl)methanone 
• 83575-55-7 2-(4-bromophenyl)-2-(trimethylsilyloxy)acetonitrile 
• 99-90-1 para-bromoacetophenone 
• 74-88-4 methyl iodide 
• 74-83-9 methyl bromide 
• 553-90-2 Dimethyl oxalate 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 63987-90-6 1-(4-bromophenyl)-2,2-dimethoxyethanone 
• 264881-99-4 methyl 2-(4-bromophenyl)-2-diazoacetate 

Downstream Products

• 143365-49-5 methyl α-(4-bromophenyl)-α-(2-furyl)-α-hydroxyacetate 
• 143365-50-8 methyl α-(4-bromophenyl)-α-(3-furyl)-α-hydroxyacetate 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 21453-02-1 3-(4-bromophenyl)quinoxalin-2-ol 

Relevant articles and documents

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Preparation method of alpha-ketoester compound

The invention discloses a preparation method of an alpha-ketone ester compound. The method specifically comprises the following operation steps: adding raw materials alpha-diazo ester and an organic photocatalyst into a reaction flask, then adding an organic solvent, and reacting for 2-12 hours in air at room temperature under the irradiation of a visible light lamp; after the reaction is monitored by thin-layer chromatography (TLC), stopping the reaction, and extracting a reaction solution by using ethyl acetate; concentrating the extracting solution under reduced pressure to obtain a crude product, and performing column chromatography separation on the crude product to obtain the alpha-diazonium ester compound. According to the preparation method, clean visible light is used as reaction energy, cheap organic dye is used as a photocatalyst, air is used as a green oxidizing agent and an oxygen source, and the preparation method has the advantages of simplicity and convenience in operation, no metal residue and mild reaction conditions.