57734-57-3

Basic information

• Product Name: (2-Pyrrolidinyl)methylamine
• Synonyms: 2-(AMINOMETHYL)PYRROLIDINE;PYRROLIDIN-2-YLMETHANAMINE;(2-Pyrrolidinyl)methylamine;2-(Aminomethyl)pyrrolidine dihydrochloride;2-(AMinoMethyl)pyrrolidine hydrochloride;pyrrolidin-2-ylMethanaMine hydrochloride;2-Pyrrolidinemethanamine;pyrrolidin-2-ylmethylamine
• CAS NO: 57734-57-3
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.16
• Mol File: 57734-57-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 152.9 °C at 760 mmHg
• Flash Point: 48.9 °C
• Appearance: /
• Density: 0.914 g/cm3
• Vapor Pressure: 3.42mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.68±0.10(Predicted)
• CAS DataBase Reference: (2-Pyrrolidinyl)methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Pyrrolidinyl)methylamine(57734-57-3)
• EPA Substance Registry System: (2-Pyrrolidinyl)methylamine(57734-57-3)

Safety Data

• Hazardous Substances Data: 57734-57-3(Hazardous Substances Data)

Usage

General Description

(2-Pyrrolidinyl)methylamine, also known as PMMA, is a chemical compound with the formula C6H13N. It is a tertiary amine with a pyrrolidine ring, and it has a variety of industrial and research applications. PMMA is commonly used as a building block for the synthesis of other chemicals, including pharmaceuticals and agrochemicals. It is also used in the production of polymers, plastics, and organic coatings. PMMA is a colorless liquid with a strong odor, and it is considered to be a hazardous substance that should be handled with caution. It is important to use proper safety precautions when working with PMMA to ensure the health and safety of individuals and the environment.

InChI:InChI=1/C5H12N2/c6-4-5-2-1-3-7-5/h5,7H,1-4,6H2

Upstream product

• 259537-92-3 tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate 
• 62937-47-7 (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 344-25-2 D-Prolin 
• 6404-31-5 Z-D-proline 
• 62937-45-5 (R)-prolinamide 
• 2812-47-7 pyrrolidine-2-carboxylic acid amide 
• 1003-29-8 2-pyrrole aldehyde 
• 960622-17-7 (E)-pyrrole-2-carboxaldehyde oxime 
• 108-24-7 acetic anhydride 
• 30130-35-9 N-acetylprolinamide 
• 64608-72-6 (1H-pyrrol-2-yl)methylamine 

Downstream Products

• 956467-82-6 N-[((2R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-3,4-bis(methyloxy)benzenesulfonamide 
• 1206103-64-1 (4aS,13aR)-8-bromo-10-[(phenylmethyl)oxy]-2,3,4a,5,13,13a-hexahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-9,11-dione 
• 2856-81-7 1-(4-fluoro-phenyl)-4-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-butan-1-one 
• 88327-67-7 4-(β-phenylethyl)-1,4-diazabicyclo<4.3.0>nonane 
• 5654-83-1 octahydropyrrolo[1,2-a]pyrazine 
• 88327-69-9 1-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol 
• 88327-68-8 4-(β-phen yl-β-hydroxyethyl)-1,4-diazabicyclo<4.3.0>nonane 
• 88327-70-2 4-(2-oxo-4-n-butyl)-1,4-diazabicyclo<4.3.0>nonane 
• 88327-66-6 4-ethyl-1,4-diazabicyclo<4.3.0>nonane 
• 956468-16-9 N-[((2R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-3,4-bis(methyloxy)benzenesulfonamide 
• 685126-24-3 3-{2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-3-chloro-phenyl}-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazole 
• 88327-63-3 2,3-dioxo-1,4-diazabicyclo<4.3.0>nonane 

Relevant articles and documents

Enantioselective Synthesis of 2-Aminomethyl and 3-Amino Pyrrolidines and Piperidines through 1,2-Diamination of Aldehydes

An efficient method for the synthesis of 1,2-diamines from aldehydes through proline-catalyzed asymmetric α-amination followed by reductive amination is reported. The products resemble those obtained through direct asymmetric diamination of terminal alkenes. The methodology is used to synthesize 2-aminomethyl and 3-amino pyrrolidines and piperidines in high yields and with a good enantioselectivity. The usefulness of the method is demonstrated through the synthesis of a 2-aminomethyl iminocyclitol.

Biomimetic asymmetric aldol reactions catalyzed by proline derivatives attached to β-cyclodextrin in water

Two proline derivatives, (S)-2-aminomethylpyrrolidine and (R)-2-aminomethylpyrrolidine modified β-CD (CD-1, CD-2) were synthesized in the yields of 31% and 14%. Their self-inclusion conformations were characterized by 1H ROESY NMR studies and q

CHEMICAL COMPOUNDS

The present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use of the same.