88327-66-6

Basic information

• Product Name: Pyrrolo[1,2-a]pyrazine, 2-ethyloctahydro- (9CI)
• Synonyms: Pyrrolo[1,2-a]pyrazine, 2-ethyloctahydro- (9CI);2-ETHYLOCTAHYDRO-PYRROLO[1,2-A]PYRAZINE
• CAS NO: 88327-66-6
• Molecular Formula: C9H18N2
• Molecular Weight: 154.25262
• Product Categories: PIPERIDINE
• Mol File: 88327-66-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrrolo[1,2-a]pyrazine, 2-ethyloctahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-a]pyrazine, 2-ethyloctahydro- (9CI)(88327-66-6)
• EPA Substance Registry System: Pyrrolo[1,2-a]pyrazine, 2-ethyloctahydro- (9CI)(88327-66-6)

Safety Data

• Hazardous Substances Data: 88327-66-6(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 5654-83-1 octahydropyrrolo[1,2-a]pyrazine 
• 88327-63-3 2,3-dioxo-1,4-diazabicyclo<4.3.0>nonane 
• 57734-57-3 2-amino-methylpyrrolidine 

Relevant articles and documents

Studies in Potential Filaricides: Part XIII - Synthesis of 1,4-Diazabicyclononanes, 1,4-Diazabicyclodecanes and 1,4-Diazabicycloundecanes as diethylcarbamazine Analogs

1,4-Diazabicyclononanes (13 - 20), 1,4-diazabicyclodecanes (21 - 28), 1,4-diazabicycloundecanes (29 - 34), 1,4-diazabicyclononan-5-ones (37 - 41) and 1,4-diazabicyclodecan-5-ones (42 - 44) having alkyl and acyl substituents at 4-position have been synthesized and evaluated for their filaricidal activity against Litomasoides carinii infection in cotton rats.Except 4-diethylcarbamoyl-1,4-diazabicyclononane (13), which exhibits significant activity, being about 3/5th as active as the standard diethylcarbamazine (DEC), none of the other compounds shows any activity against adult worms.The results have been rationalised in terms of critical bulk around the N-1 of the piperazine ring of DEC.From this work and earlier published results it appears that both axial and equatorial N-CH3 bonds in DEC are acceptable for activity.