5779-99-7

Basic information

• Product Name: 4-Methoxy-1,3-benzodioxole-5-carbaldehyde
• Synonyms: 4-Methoxy-1,3-benzodioxole-5-carbaldehyde;2-Methoxypiperonal
• CAS NO: 5779-99-7
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Product Categories: Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 5779-99-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Methoxy-1,3-benzodioxole-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1,3-benzodioxole-5-carbaldehyde(5779-99-7)
• EPA Substance Registry System: 4-Methoxy-1,3-benzodioxole-5-carbaldehyde(5779-99-7)

Safety Data

• Hazardous Substances Data: 5779-99-7(Hazardous Substances Data)

Usage

Uses

2-Methoxypiperonal is an intermediate in the synthesis of Cotarnine Chloride (C717500), an oxidative degradation product of the drug Noscapine (N882000).

Upstream product

• 23780-59-8 4-hydroxybenzo[d][1,3]dioxole-5-carbaldehyde 
• 74-88-4 methyl iodide 
• 120-57-0 piperonal 
• 59259-90-4 5-(dimethoxymethyl)benzo[d][1,3]dioxole 
• 77-78-1 dimethyl sulfate 
• 58343-44-5 2-Iodo-3,4-(methylendioxy)benzaldehyde cyclohexylimine 
• 1817-95-4 4-methoxy-benzo[1,3]dioxole 
• 93-61-8 N-methyl-N-phenylformamide 
• 10025-87-3 trichlorophosphate 
• 68-12-2 N,N-dimethyl-formamide 
• 934-00-9 3-methocycatechol 
• 74-95-3 1,1-dibromomethane 
• 91129-06-5 2-Methoxy-3,4-(methylendioxy)benzaldehyde Cyclohexylimine 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 750649-61-7 8-(Diphenyl-phosphinoyl)-7-(4-methoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one 
• 750649-58-2 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one 
• 750649-53-7 4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide 
• 750649-56-0 4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-(4-methoxy-benzyl)-amide 
• 477-82-7 evoxanthine 
• 1329120-31-1 C₂₆H₂₇NO₈S 
• 1329120-32-2 C₂₆H₂₉NO₈S 
• 1329120-33-3 C₃₂H₄₃NO₈SSi 
• 128-62-1 (±)-α-noscapine 
• 108261-07-0 5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo<4,5-g>isoquinolin-8-ol 
• 30936-27-7 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide 
• 5985-55-7 Hydrocotarnine hydrochloride 
• 108434-79-3 5,6,7,8-Tetrahydro-8-acetoxy-4-methoxy-6-methyl-1,3-dioxolo<4,5-g>isoquinoline 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 

Relevant articles and documents

A new total synthesis of (±)-α-noscapine

A new, convergent total synthesis of (±)-α-noscapine was developed on a grams scale through the condensation of 3-trimethylsilyl-meconin derivative 9 and the iodized salt cotarnine derivative 20 as the key step. Staring from simple 2,3-dimethoxybenzoic acid, piperonal and 2,2-dimethoxyethanamine, through the traditional chemical processes to give the final product in 11.6% yield over 14 steps.

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation

The synthesis of two C-1 analogues of pancratistatin has been accomplished in 17 steps from bromobenzene. The key steps involved the enzymatic dihydroxylation, regioselective opening of epoxyaziridine 9 with the alane derived from 8, a solid-state silica-

A convenient synthesis of 4-alkoxylated isoindolin-1-ones

A short synthesis of 4-alkoxylated isoindolin-1-ones based upon the S NAr reaction applied to phosphorylated 2-methoxybenzamides followed by alkaline cleavage of the phosphoryl auxiliary is reported.