58023-19-1

Basic information

• Product Name: NSC 240403
• Synonyms: N,N-Bis(2-chloroethyl)benzenesulfonaMide;NSC 240403
• CAS NO: 58023-19-1
• Molecular Formula: C₁₀H₁₃Cl₂NO₂S
• Molecular Weight: 282.18672
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 58023-19-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 398.4°Cat760mmHg
• Flash Point: 194.7°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 1.48E-06mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform, Ethyl Acetate, Methanol
• Stability: Hygroscopic
• CAS DataBase Reference: NSC 240403(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 240403(58023-19-1)
• EPA Substance Registry System: NSC 240403(58023-19-1)

Safety Data

• Hazardous Substances Data: 58023-19-1(Hazardous Substances Data)

Usage

Uses

N,N-Bis(2-chloroethyl)benzenesulfonamide is a novel intermediate in the synthesis of Cetirizine (C281100).

InChI:InChI=1/C10H13Cl2NO2S/c11-6-8-13(9-7-12)16(14,15)10-4-2-1-3-5-10/h1-5H,6-9H2

Upstream product

• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 98-09-9 benzenesulfonyl chloride 
• 13127-79-2 N-benzenesulfonyl-bis(2-hydroxyethyl)amine 

Downstream Products

• 100317-19-9 1-ethyl-4-benzenesulfonyl-piperazine 
• 100800-52-0 1-benzenesulfonyl-4-isopropyl-piperazine 
• 1092460-01-9 (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(phenyl)sulfonyl]piperazine 
• 1357621-11-4 N,N-bis[2-(4-cyanophenoxy)ethyl]benzenesulfonamide 
• 1357621-15-8 N,N-bis[2-(4-cyano-2,6-dimethoxyphenoxy)ethyl]benzenesulfonamide 
• 1357621-13-6 N,N-bis[2-(4-cyano-2-methoxyphenoxy)ethyl]benzenesulfonamide 
• 1391052-52-0 (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(phenyl)sulfonyl]piperazine 
• 101730-55-6 1-benzenesulfonyl-4-phenyl-piperidine-4-carboxylic acid 
• 66739-87-5 4-methylpiperazin-1-ylbenzenesulfonamide 
• 101793-30-0 1-benzenesulfonyl-4-phenyl-piperidine-4-carbonitrile 
• 100800-53-1 1-benzenesulfonyl-4-propyl-piperazine 

Relevant articles and documents

PROCESS FOR PREPARATION OF SUBSTANTIALLY OPTICALLY PURE LEVOROTATORY AND DEXTROROTATORY ENANTIOMERS OF CETIRIZINE USING NOVEL INTERMEDIATES

The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.