66739-87-5

Basic information

• Product Name: 1-methyl-4-(phenylsulfonyl)piperazine
• Synonyms: 1-methyl-4-(phenylsulfonyl)piperazine
• CAS NO: 66739-87-5
• Molecular Formula: C₁₁H₁₆N₂O₂S
• Molecular Weight: 240.32194
• Mol File: 66739-87-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 363.7°C at 760 mmHg
• Flash Point: 173.8°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 1.77E-05mmHg at 25°C
• Refractive Index: 1.572
• PKA: 6.18±0.42(Predicted)
• CAS DataBase Reference: 1-methyl-4-(phenylsulfonyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-(phenylsulfonyl)piperazine(66739-87-5)
• EPA Substance Registry System: 1-methyl-4-(phenylsulfonyl)piperazine(66739-87-5)

Safety Data

• Hazardous Substances Data: 66739-87-5(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivative
A heterocyclic amine with a six-membered ring and two opposing nitrogen atoms.

Structural modification

Addition of functional groups
A methyl group at the 1-position and a phenylsulfonyl group at the 4-position.

Potential applications

Pharmaceutical and medicinal chemistry
Studied for their potential use as antipsychotic, antidepressant, and anxiolytic drugs.

Pharmacological effects

Influence of phenylsulfonyl group
May contribute to the compound's therapeutic effects and could be a target for further research and development of new therapeutic agents.

InChI:InChI=1/C11H16N2O2S/c1-12-7-9-13(10-8-12)16(14,15)11-5-3-2-4-6-11/h2-6H,7-10H2,1H3

Upstream product

• 14172-55-5 1-(phenylsulphonyl)piperazine 
• 80-18-2 Methyl benzenesulfonate 
• 58023-19-1 N-benzenesulfonyl-N,N-bis(2-chloroethyl)amine 
• 124-40-3 dimethyl amine 
• 108-86-1 bromobenzene 
• 109-01-3 1-methyl-piperazine 
• 108-98-5 thiophenol 
• 80-17-1 benzenesufonyl hydrazide 
• 938-10-3 phenylsulfonyl azide 
• 837-12-7 1-((4-bromophenyl)sulfonyl)-4-methylpiperazine 
• 27106-46-3 1-Benzolsulfonyl-4-ethoxycarbonyl-piperazin 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 109-01-3 1-methyl-piperazine 

Relevant articles and documents

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.

Three-component synthesis of N-sulfonylformamidines in the presence of magnetic cellulose supported N-heterocyclic carbene-copper complex, as an efficient heterogeneous nanocatalyst

A cellulose based magnetic nanocomposite possessing NHC-Cu Complex has been synthesized and characterized. It was then applied as a highly active catalyst in one-pot three-component reaction of sulfonyl azides, secondary amines and triethylamine to afford