58114-09-3

Basic information

• Product Name: 1-(1-chloroethyl)-3-fluorobenzene
• Synonyms: 1-(1-chloroethyl)-3-fluorobenzene
• CAS NO: 58114-09-3
• Molecular Weight: 158.603
• Mol File: 58114-09-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1-chloroethyl)-3-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-chloroethyl)-3-fluorobenzene(58114-09-3)
• EPA Substance Registry System: 1-(1-chloroethyl)-3-fluorobenzene(58114-09-3)

Safety Data

• Hazardous Substances Data: 58114-09-3(Hazardous Substances Data)

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 402-63-1 1-(3-fluorophenyl)ethanol 

Downstream Products

• 402-63-1 1-(3-fluorophenyl)ethanol 

Relevant articles and documents

Thiourea-Mediated Halogenation of Alcohols

The halogenation of alcohols under mild conditions expedited by the presence of substoichiometric amounts of thiourea additives is presented. The amount of thiourea added dictates the pathway of the reaction, which may diverge from the desired halogenation reaction toward oxidation of the alcohol, in the absence of thiourea, or toward starting material recovery when excess thiourea is used. Both bromination and chlorination were highly efficient for primary, secondary, tertiary, and benzyl alcohols and tolerate a broad range of functional groups. Detailed electron paramagnetic resonance (EPR) studies, isotopic labeling, and other control experiments suggest a radical-based mechanism. The fact that the reaction is carried out at ambient conditions, uses ubiquitous and inexpensive reagents, boasts a wide scope, and can be made highly atom economic, makes this new methodology a very appealing option for this archetypical organic reaction.