59207-23-7

Basic information

• Product Name: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE
• Synonyms: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE;2-methyl-5H-thieno[3,2-c]pyridin-4-one;2-Methylthieno[3,2-c]pyridin-4(5H)
• CAS NO: 59207-23-7
• Molecular Formula: C8H7NOS
• Molecular Weight: 165.22
• Mol File: 59207-23-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 415.8 °C at 760 mmHg
• Flash Point: 205.3 °C
• Appearance: /
• Density: 1.292
• Vapor Pressure: 4.01E-07mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.00±0.20(Predicted)
• CAS DataBase Reference: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(59207-23-7)
• EPA Substance Registry System: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(59207-23-7)

Safety Data

• Hazardous Substances Data: 59207-23-7(Hazardous Substances Data)

Usage

General Description

2-methylthieno[3,2-c]pyridin-4(5H)-one is a chemical compound with a molecular formula of C7H5NOS. It is a heterocyclic compound that contains a thieno[3,2-c]pyridine skeleton, which is a fused ring system comprising a thiophene and a pyridine ring. 2-methylthieno[3,2-c]pyridin-4(5H)-one is used in the synthesis of various pharmaceuticals and agrochemicals due to its potential biological activity. It also possesses a variety of potential applications in the field of organic chemistry, including as a building block for the synthesis of more complex molecules. Additionally, it is used as a reagent in organic synthesis for the preparation of diverse organic compounds.

InChI:InChI=1/C8H7NOS/c1-5-4-6-7(11-5)2-3-9-8(6)10/h2-4H,1H3,(H,9,10)

Upstream product

• 70329-36-1 (E)-3-(5-methyl-2-thienyl)-2-propenoic caid 
• 59207-22-6 C₈H₇N₃OS 
• 14770-88-8 3-(5-methylthiophen-2-yl)acrylic acid 
• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 59207-21-5 (E)-3-(5-Methyl-thiophen-2-yl)-acryloyl chloride 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1472655-07-4 C₂₉H₂₇NO₅S₂ 
• 1472655-06-3 C₂₉H₂₇NO₆S 
• 59207-24-8 4-Chloro-2-methyl-thieno[3,2-c]pyridine 

Relevant articles and documents

3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones

A 3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones, using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (tR 2 min) in 100-W blue LED light that minimizes the formation of dark, insoluble decomposition products is a tangible benefit of this technology.

A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo -bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.

Design and synthesis of piperazinylpyridine derivatives as novel 5-HT 1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS)

We have prepared a series of piperazinylpyridine derivatives for the treatment of irritable bowel syndrome (IBS). These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT 1A) and subtype 3 (5-HT3) receptors. The nitrogen atom of the isoquinoline, a methoxy group and piper-azine were essential to the pharmacophore for binding to these receptors. We also synthesized furo- and thienopyridine derivatives according to structure-activity relationship analyses. Compound 17c (TZB-20810) had high affinities to these receptors and exhibited 5-HT1A agonistic activity and 5-HT3 antagonistic activity concurrently, and is a promising drug for further development in the treatment of IBS.