59207-24-8

Basic information

• Product Name: 4-CHLORO-2-METHYLTHIENO[3,2-C]PYRIDINE
• Synonyms: 4-CHLORO-2-METHYLTHIENO[3,2-C]PYRIDINE;4-chloro-2-Methylthieno[3
• CAS NO: 59207-24-8
• Molecular Formula: C₈H₆ClNS
• Molecular Weight: 183.66
• Product Categories: CHIRAL CHEMICALS
• Mol File: 59207-24-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.253 °C at 760 mmHg
• Flash Point: 126.922 °C
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.06±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHYLTHIENO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLTHIENO[3,2-C]PYRIDINE(59207-24-8)
• EPA Substance Registry System: 4-CHLORO-2-METHYLTHIENO[3,2-C]PYRIDINE(59207-24-8)

Safety Data

• Hazardous Substances Data: 59207-24-8(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-methylthieno[3,2-c]pyridine is a chemical compound with the molecular formula C8H6ClNS. It is a heterocyclic compound that contains a thiophene ring fused to a pyridine ring with a chlorine and a methyl group attached to it. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research. Its unique structure and reactivity make it a valuable intermediate in the production of various biologically active molecules, such as pharmaceutical drugs and agrochemicals. It is also known for its potential use as a pesticide and an antimicrobial agent due to its inhibitory effects on the growth of certain organisms. Overall, 4-chloro-2-methylthieno[3,2-c]pyridine is an important chemical compound with versatile applications in the fields of medicine, agriculture, and chemical research.

InChI:InChI=1/C8H6ClNS/c1-5-4-6-7(11-5)2-3-10-8(6)9/h2-4H,1H3

Upstream product

• 59207-23-7 2-methylthieno[3,2-c]pyridin-4(5H)-one 

Downstream Products

• 497-09-6 (S)-glyceraldehyde 

Relevant articles and documents

Design and synthesis of piperazinylpyridine derivatives as novel 5-HT 1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS)

We have prepared a series of piperazinylpyridine derivatives for the treatment of irritable bowel syndrome (IBS). These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT 1A) and subtype 3 (5-HT3) receptors. The nitrogen atom of the isoquinoline, a methoxy group and piper-azine were essential to the pharmacophore for binding to these receptors. We also synthesized furo- and thienopyridine derivatives according to structure-activity relationship analyses. Compound 17c (TZB-20810) had high affinities to these receptors and exhibited 5-HT1A agonistic activity and 5-HT3 antagonistic activity concurrently, and is a promising drug for further development in the treatment of IBS.

1-SUBSTITUTED AMINO-3-THIENO-[3,2-c]PYRIDINYLOXY-2-PROPANOLS

This invention provides new compounds of formula I, STR1 wherein X is sulphur or oxygen,R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, α-dialkylpropinyl of 5 to 9 carbon atoms or α-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound, R 1 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2,3,6 or 7 position, orIi. chlorine or bromine, in the 2, 3 or 7 position,Iii. nitro or--NHA wherein A is alkanoyl of 1 to 4 carbon atoms, in the 2, 3 or 7 position, orIv. fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, andR 2 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2, 3, 6 or 7 position,Ii. chlorine or bromine, in the 2, 3 or 7 position, orIii. fluorine in the 2 or 3 position,Useful in the treatment of heart diseases.