5939-37-7 Usage
Chemical Properties
Yellow Solid
Uses
7-Hydroxy Methotrexate is a metabolite of Methotrexate, which is used as a antineoplastic and antirheumatic.
Check Digit Verification of cas no
The CAS Registry Mumber 5939-37-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,3 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5939-37:
(6*5)+(5*9)+(4*3)+(3*9)+(2*3)+(1*7)=127
127 % 10 = 7
So 5939-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N8O6/c1-28(8-12-18(32)26-16-14(23-12)15(21)25-20(22)27-16)10-4-2-9(3-5-10)17(31)24-11(19(33)34)6-7-13(29)30/h2-5,11H,6-8H2,1H3,(H,24,31)(H,29,30)(H,33,34)(H5,21,22,25,26,27,32)/t11-/m0/s1
5939-37-7Relevant articles and documents
Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin
Dawson,O'Krongly,Hobbs,Barrueco,Sirotnak
, p. 635 - 638 (2007/10/02)
The potent folate antagonists methotrexate and 10-ethyl-10-deazaaminopterin are oxidized in vivo to their 7-hydroxy derivatives. A specific cyanation at the C-7 position of the pteridine ring system using diethyl phosphorocyanidate converted the dimethyl esters of methotrexate and 10-ethyl-10-deazaaminopterin to the corresponding 7-cyano dimethyl ester derivatives, which were hydrolyzed to the 7-hydroxy metabolites.
