59394-98-8

Basic information

• Product Name: (E)-N'-benzylidene-4-methylbenzohydrazide
• Synonyms: (E)-N'-benzylidene-4-methylbenzohydrazide
• CAS NO: 59394-98-8
• Molecular Weight: 238.289
• Mol File: 59394-98-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N'-benzylidene-4-methylbenzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N'-benzylidene-4-methylbenzohydrazide(59394-98-8)
• EPA Substance Registry System: (E)-N'-benzylidene-4-methylbenzohydrazide(59394-98-8)

Safety Data

• Hazardous Substances Data: 59394-98-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3619-22-5 p-toluic hydrazide 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 99-94-5 p-Toluic acid 
• 4335-90-4 3-benzylidene acetylacetone 

Downstream Products

• 77420-75-8 [1-Phenyl-meth-(E)-ylidene]-(5-p-tolyl-[1,3,4]thiadiazol-2-yl)-amine 
• 77420-70-3 N-[1-Phenyl-meth-(E)-ylidene]-N'-[1-thiocyanato-1-p-tolyl-meth-(Z)-ylidene]-hydrazine 
• 100-47-0 benzonitrile 
• 619-55-6 para-methylbenzamide 
• 36342-43-5 C₁₅H₁₃ClN₂ 
• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.

Unsaturated Compounds containing Nitrogen. Part 4. Further Reactions of 1-Chloro-2,3-diazabutadienes with S-Nucleophiles

1-Chloro-1,4-diaryl-2,3-diazabutadienes (Ar1CCl=NN=CHAr2), prepared by the reaction of thionyl chloride with aroylhydrazones (Ar1CONHN=CHAr2), react with thiosemicarbazide or thiocarbohydrazide to give 2-arylidenehydrazino-5-aryl-1,3,4-thiadiazoles, and with potassium thiocyanate to give 1-thiocyanato-1,4-diaryl-2,3-diazabutadienes which isomerize thermally to arylideneamino-5-aryl-1,3,4-thiadiazoles. 1-Chloro-1,4-diphenyl-2,3-diazabutadiene reacts with potassium ethylxanthate to give a 1-ethylxanthyl-2,3-diazabutadiene which on pyrolysis yields 2,5-diphenyl-1,3,4-thiadiazole.