1874-47-1

Basic information

• Product Name: 2-(4-METHYLPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE
• Synonyms: 2-(4-METHYLPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE
• CAS NO: 1874-47-1
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.27
• Mol File: 1874-47-1.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 389 °C at 760 mmHg
• Flash Point: 186 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 6.6E-06mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-(4-METHYLPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(1874-47-1)
• EPA Substance Registry System: 2-(4-METHYLPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(1874-47-1)

Safety Data

• Hazardous Substances Data: 1874-47-1(Hazardous Substances Data)

Usage

General Description

2-(4-Methylphenyl)-5-phenyl-1,3,4-oxadiazole, also known as MPPO, is a chemical compound that belongs to the oxadiazole family. It is a white or pale yellow solid that is insoluble in water but soluble in organic solvents. MPPO is widely used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and materials. It is also used as a fluorescent dye and a sensor for detecting heavy metal ions. MPPO has potential applications in the fields of medicine, agriculture, and environmental monitoring due to its unique chemical and fluorescent properties. However, as with any chemical compound, proper handling and storage of MPPO are important to ensure safety and prevent any potential hazards.

InChI:InChI=1/C15H12N2O/c1-11-7-9-13(10-8-11)15-17-16-14(18-15)12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 59635-52-8 N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 3619-22-5 p-toluic hydrazide 
• 7253-65-8 4-methyl benzaldehyde benzoylhydrazone 
• 59394-98-8 (E)-N'-benzylidene-4-methylbenzohydrazide 
• 613-94-5 benzoic acid hydrazide 
• 99-94-5 p-Toluic acid 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 13222-85-0 p-methylbenzoic anhydride 
• 104-87-0 4-methyl-benzaldehyde 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 5720-05-8 4-methylphenylboronic acid 
• 100-52-7 benzaldehyde 
• 24994-04-5 5-(4-methylphenyl)-2H-tetrazole 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 

Downstream Products

• 1557164-62-1 4-(5-phenyl-1,3,4-thiadiazol-2-yl)benzaldehyde 
• 1203959-20-9 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-thiadiazole 
• 16112-32-6 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole 
• 21464-13-1 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-oxadiazole 
• 65145-92-8 diethyl 4-(5-(phenyl)-1,3,4-oxadiazol-2-yl)benzylphosphonate 
• 1331841-32-7 2-(4-(3,4-dichlorostyryl)phenyl)-5-phenyl-1,3,4-oxadiazole 
• 1384517-07-0 2-(4-(2,4-dichlorostyryl)phenyl)-5-phenyl-1,3,4-oxadiazole 
• 65965-70-0 4-[s-triazolo[1,5-a]pyrid-2-yl]-4'-(5-phenyl-1,3,4-oxadiazol-2-yl)-stilbene 
• 71943-35-6 2-(4-{4-[4,5-dichloro-1-(4-chloro-phenyl)-1H-pyrazol-3-yl]-styryl}-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 71943-34-5 2-(4-{4-[4-chloro-1-(4-chloro-phenyl)-1H-pyrazol-3-yl]-styryl}-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 71943-33-4 2-(4-{4-[1-(4-chloro-phenyl)-1H-pyrazol-3-yl]-styryl}-phenyl)-5-phenyl-[1,3,4]oxadiazole 

Relevant articles and documents

Halogen bonding two-point recognition with terphenyl derivatives

Two-point recognition involving neutral terphenyl-based halogen bond donors (halogen-based Lewis acids) was investigated. Oxadiazole and pyridazole derivatives were identified by DFT as suitable binding partners, even though gas-phase binding was weak. X-

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions

1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive molecules. In this study, intermolecular electrochemical cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91 %. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation.

UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.