5955-73-7Relevant articles and documents
Preparation method of O-methylbenzoyl nitrile
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Paragraph 0054; 0057-0060; 0063-0066; 0069-0072; 0075-0078;, (2021/11/21)
The method comprises the following steps: firstly dissolving o-methylbenzoic acid in a toluene solvent, dropping the dimethyl sulfoxide to carry out reaction, and removing a small amount of unreacted dichlorosulphoxide at low temperature after the reactio
A stretching of the intermediate O-methyl benzoyl nitrile synthetic method
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Paragraph 0030; 0031; 0032; 0033; 0034; 0035; 0036-0041, (2017/03/22)
The invention relates to a method for preparing a key intermediate methylbenzoyl cyanide in the process of synthesizing trifloxystrobin. The method comprises the following steps: adding o-toluoyl chloride, a solvent and a catalyst into a reaction kettle; introducing metered hydrocyanic acid gas, completely reacting under a heat insulating conditon to obtain methylbenzoyl cyanide, and carrying out back-distillation to obtain a methylbenzoyl cyanide product. The content of methylbenzoyl cyanide is over 99 percent and the yield can be over 95 percent metered in form of o-toluoyl chloride. The method is simple and convenient to operate, the utilization of the raw material o-toluoyl chloride is high; except the byproduct hydrochloric acid, almost no other wastes are generated, and atomic economic reaction is basically realized. The method is a synthesizing process with good economic prospect.
Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes
Li, Meina,Kong, Duanyang,Zi, Guofu,Hou, Guohua
, p. 680 - 687 (2017/04/26)
A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.