60200-06-8 Usage
Description
Clorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 60200-06-8 differently. You can refer to the following data:
1. analgesic, antiinflammatory
2. A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes)
3. A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).
Brand name
Curatrem [Veterinary] (Merial).
Veterinary Drugs and Treatments
Clorsulon is approved for use in the treatment of immature and
adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective
against immature flukes less than 8 weeks old. It also has activity
against Fasciola gigantica. Although not approved, the drug has
been used in practice in various other species (e.g., sheep, llamas).
It has activity against F. magna in sheep, but is not completely effective
in eradicating the organism after a single dose, thus severely
limiting its clinical usefulness against this parasite. Clorsulon is also
not effective against the rumen fluke (Paramphistomum).
Check Digit Verification of cas no
The CAS Registry Mumber 60200-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,0 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60200-06:
(7*6)+(6*0)+(5*2)+(4*0)+(3*0)+(2*0)+(1*6)=58
58 % 10 = 8
So 60200-06-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
60200-06-8Relevant articles and documents
A method for preparing chlorine Shu Long
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Paragraph 0035; 0036, (2017/02/17)
The invention discloses a preparation method of clorsulon. The preparation method comprises the steps: carrying out condensation on m-nitrobenzaldehyde with chloroform at a low temperature, then chloridizing, and carrying out elimination, hydrazine hydrate reduction, chlorosulfuric acid sulphonation and ammonification to obtain clorsulon. The use of benzene with relatively high toxicity is avoided, the use of chlorine with relatively large dangerousness is also avoided, the reduction reaction adopts more environmentally-friendly hydrazine hydrate, hydrazine hydrate reduction has less solid waste than iron powder reduction, an excellent catalyst ferric trichloride and an activated carbon carrier are selected, a by-product nitrogen gas has a good protective effect on the product, the product quality is high, the yield is equivalent to the yield reported in literature, the process is simplified, reaction conditions are mild, and the preparation method is environmentally friendly and has good industrial application prospects.
Halogenated unsaturated alkyl benzenedisulfonamides as anthelmintics
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, (2008/06/13)
Novel substituted benzenedisulfonamides are disclosed which compounds are active anthelmintic agents being particularly useful against fascioliasis in sheep and cattle. Specifically the active compounds are 4-amino-1,3-benzenedisulfonamide with an unsaturated substituted alkyl group. Compositions and methods containing the novel substituted benzenedisulfonamides for use in anthelmintic therapy particularly against liver fluke are also disclosed.
