63630-19-3Relevant articles and documents
4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
Mrozik,Bochis,Eskola,Matzuk,Waksmunski,Olen,Schwartzkopf Jr.,Grodski,Linn,Lusi,Wu,Shunk,Peterson,Milkowski,Hoff,Kulsa,Ostlind,Campbell,Riek,Harmon
, p. 1225 - 1227 (2007/10/06)
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3- benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.