602326-63-6Relevant articles and documents
A concise and efficient synthesis of spiroketals - Application to the synthesis of SPIKET-P and a spiroketal from bactrocera species
Tomas, Loic,Bourdon, Benjamin,Caille, Jean Claude,Gueyrard, David,Goekjian, Peter G.
, p. 915 - 920 (2013/03/28)
We report the synthesis of spiroketals by sequence of enol ether synthesis and cyclization. The enol ethers were prepared from lactones by a Julia olefination reaction, and the starting chiral lactone was prepared from an industrial intermediate. This route is a concise and efficient way to synthesize naturally occurring and biologically interesting spiroketals. We used this sequence for the preparation of SPIKET-P and a spiroketal from Bactrocera species. Copyright
The first total synthesis of (S)-clavulazine from d-mannitol
Kumar, S. Praveen,Nagaiah,Chorghade, Mukund S.
, p. 7149 - 7151 (2007/10/03)
The first total synthesis of the marine natural product, (S)-clavulazine has been accomplished. d-Mannitol was used as a chiral starting material. Enantioselective zinc-mediated allylation, and ring-closing metathesis are the key steps in the synthesis. S
