60342-56-5

Basic information

• Product Name: disodium N-(phosphonatoacetyl)aspartic acid
• CAS NO: 60342-56-5
• Molecular Formula: C₆H₆NO₈P*4Na
• Molecular Weight: 299.0829
• Mol File: 60342-56-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: disodium N-(phosphonatoacetyl)aspartic acid(CAS DataBase Reference)
• NIST Chemistry Reference: disodium N-(phosphonatoacetyl)aspartic acid(60342-56-5)
• EPA Substance Registry System: disodium N-(phosphonatoacetyl)aspartic acid(60342-56-5)

Safety Data

• Hazardous Substances Data: 60342-56-5(Hazardous Substances Data)

Upstream product

• 67036-33-3 N-chloroacetyl-L-aspartic acid 
• 56-84-8 L-Aspartic acid 
• 118903-73-4 N-(Phosphonoacetyl)-L-asparaginsaeure-di(p-nitrobenzyl)ester 
• 118903-72-3 N-(Phosphonoacetyl)-L-asparaginsaeure-di-(p-nitrobenzyl)-P,P-dimethylester 
• 76385-75-6 N-bis (trimethylsilyl) phosphonoacetyl-L-aspartate d'ethyle 
• 76385-76-7 N-bis (trimethylsilyl) phosphonoacetyl-L-aspartate de methyle 
• 76385-64-3 N-(dihydroxyphosphinyl)acetoyl-L-aspartic acid diethyl ester 
• 76385-65-4 N-phosphonoacetyl-L-aspartate de methyle 
• 71259-19-3 N-(diethoxyphosphinoyl)acetyl-L-aspartic acid diethyl ester 
• 82283-66-7 (S)-2-[2-(Dimethoxy-phosphoryl)-acetylamino]-succinic acid dimethyl ester 
• 66368-60-3 N-chloroacetyl-L-aspartic acid diethyl ester 
• 76385-50-7 (+)-dimethyl (S)-2-(2-chloroacetylamino)succinate 

Downstream Products

• 56-84-8 L-Aspartic acid 

Relevant articles and documents

Synthesis of N-(phosphonoacetyl)-L-aspartic acid (PALA)

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An Improved Synthesis of N-(Phosphonoacetyl)-amino Acids

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Preparation of N-(phosphonoacetyl)-L-aspartic acid

Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. Particular aspects of these methods include: (1) initial preparation of the PALA moiety as the dibenzyl ester; (2) the complete removal of impurities in the form of acetic acid and sodium acetate from disodium PALA by turbulent flow precipitation; and (3) preparation and purification of the cyclohexylammonium salt of dibenzyl PALA which ultimately results in a purer final product.