606093-59-8

Basic information

• Product Name: methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate
• Synonyms: 1H-BenziMidazole-5-carboxylicacid, 7-fluoro-6-(phenylaMino)-, Methyl ester;methyl 4-fluoro-5-(phenylamino)-1H-benzo[d]imidazole-6-carboxylate;Methyl 7-fluoro-6-(phenylamino)-1H-benzimidazole-5-carboxylate;methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate;Methyl 7-fluoro-6-(phenylaMino)-1H-benzo[d]iMidazole-5-carboxylate;methyl 7-fluoro-6-(phenylamino)-1H-1,3-benzodiazole-5-carboxylate
• CAS NO: 606093-59-8
• Molecular Formula: C₁₅H₁₂FN₃O₂
• Molecular Weight: 285.277
• Mol File: 606093-59-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 512.2°C at 760 mmHg
• Flash Point: 263.6°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 1.32E-10mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate(606093-59-8)
• EPA Substance Registry System: methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate(606093-59-8)

Safety Data

• Hazardous Substances Data: 606093-59-8(Hazardous Substances Data)

Usage

General Description

Methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate is a chemical compound with a complex molecular structure. It is a derivative of benzo[d]imidazole, containing a fluoro group and a phenylamino substituent. methyl 7-fluoro-6-(phenylamino)-3H-benzo[d]imidazole-5-carboxylate is commonly used in medicinal chemistry and drug development, where it may be studied for its potential pharmacological activity. It is important to handle this chemical with care due to its potential for biological and environmental impact, and strict precautions should be taken in its storage and handling.

InChI:InChI=1/C15H12FN3O2/c1-21-15(20)10-7-11-14(18-8-17-11)12(16)13(10)19-9-5-3-2-4-6-9/h2-8,19H,1H3,(H,17,18)

Upstream product

• 64-18-6 formic acid 
• 606093-58-7 4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester 
• 284030-58-6 4-Amino-2,3-difluoro-5-nitro-benzoic acid methyl ester 
• 284030-57-5 4-amino-2,3-difluoro-5-nitro-benzoic acid 
• 197520-71-1 2,3,4-trifluoro-5-nitro-benzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 606144-42-7 4,5-diamino-3-fluoro-2-phenylamino-benzoic acid methyl ester 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 606143-47-9 6-(2,4-Dichloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester 
• 606093-60-1 7-Fluoro-6-(4-iodo-phenylamino)-3H-benzoimidazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Substituted benzimidazole compound and composition with compound

The invention provides a substituted benzimidazole compound and a composition with the compound. The substituted benzimidazole compound is a compound of formula (I) as shown in the specification, or apharmaceutically acceptable salt, prodrug, aquo-complex or solvent compound, polycrystalline type compound, stereisomer or isotope variant of the compound. The compound provided by the invention canbe adopted to treat and/or prevent related diseases caused by MEK (Methyl Ethyl Ketone), such as excessive proliferative diseases, pancreatitis, kidney illness, blastocyte cell transplantation and angiogenesis or angiopoiesis related diseases.

N3 alkylated benzimidazole derivatives as MEK inhibitors

Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R1, R2, R7, R9, R10, R11 and R12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.