6065-54-9

Basic information

• Product Name: 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER
• Synonyms: 2,2-dimethyl-propanedioic acid dimethyl ester;Dimethylpropanedioic acid dimethyl ester;Propanedioic acid, dimethyl-, dimethyl ester;2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER;dimethyl 2,2-dimethylpropanedioate;DIMETHYL 2,2-DIMETHYL-MALONATE;Dimethyl dimethylmalonate
• CAS NO: 6065-54-9
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.16778
• EINECS: 1312995-182-4
• Mol File: 6065-54-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 168.6 °C at 760 mmHg
• Flash Point: 71.6 °C
• Appearance: colorless transparent liquid
• Density: 1.06 g/cm³
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: 1.416
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER(6065-54-9)
• EPA Substance Registry System: 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER(6065-54-9)

Safety Data

• Hazardous Substances Data: 6065-54-9(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-malonic acid dimethyl ester is a chemical compound with the formula C7H10O4. It is a colorless, odorless liquid that is commonly used as a reagent in organic synthesis. It is also utilized in the manufacture of pharmaceuticals and as a building block for the synthesis of complex organic molecules. 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER is highly flammable and poses a fire hazard if exposed to heat or flames. It should be handled with care and stored in a cool, dry place away from sources of ignition. Additionally, it is important to use appropriate protective gear and work in a well-ventilated area when handling this chemical.

InChI:InChI=1/C7H12O4/c1-7(2,5(8)10-3)6(9)11-4/h1-4H3

Upstream product

• 155800-02-5 S-ethyl O-methyl 2-(bromomethyl)-2-methylmonothiomalonate 
• 73879-59-1 (Brommethyl)methylmalonsaeure-dimethylester 
• 67-56-1 methanol 
• 80-62-6 methacrylic acid methyl ester 
• 186538-25-0 S-dodecyl O-methyl 2-(bromomethyl)-2-methylmonothiomalonate 
• 201230-82-2 carbon monoxide 
• 108-59-8 malonic acid dimethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 13051-21-3 3-methoxy-2,2-dimethyl-3-oxopropanoic acid 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 57772-81-3 2,2-Dimethyl-malonic acid benzyl ester methyl ester 
• 57772-82-4 dibenzyl dimethylmalonate 
• 637027-41-9 1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester 
• 1003863-64-6 2,2-dimethylmalonic acid methyl 2-phenylethyl ester 
• 488833-24-5 2,2-dimethyl-N′¹,N′³-diphenyl-N′¹,N′³-bis(phenylcarbonothioyl)malonohydrazide 
• 488831-58-9 C₂₁H₂₄N₄O₂S₂ 
• 24448-94-0 5,5-dimethylbarbituric acid 
• 595-46-0 2,2-dimethylmalonic acid 
• 68734-79-2 methyl 2-methyl-2-(phenylsulfanyl)propionate 
• 155199-55-6 dimethyl-malonic acid bis-methylamide 

Relevant articles and documents

The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase.

The rearrangement of 2-bromomethyl-2-methylmonothiomalonates to succinyl derivatives was found to take place in quantitative yields in the presence of one molar equivalent of Co(I) generated by the reduction of heptamethyl Co(II)yrinate perchlorate with NaBH4 or electrochemically. The chiral thiomalonate gave racemic succinate.

30. On the Regioselectivity Control in the Palladium-Catalyzed Hydro-alkoxycarbonylation of α,β-Unsaturated Esters

The regioselectivity of the hydro-alkoxycarbonylation of methyl acrylate, methacrylate, and crotonate catalyzed by complexes (L = phosphine ligands) can be largely controlled by variation of the ligands.PPh3 promotes preferential carbonylation a

Process to produce silyl ketene acetals

A process for the preparation of silyl ketene acetals of the formulae, from the reaction of a malonate compound with a triorganohalosilane in the presence of an alkali metal. The malonate compounds are dialkyl dialkylmalonates, bis(trialkylsilyl) dialkylmalonates, and dialkylmalonic acids. The triorganohalosilane is present in stoichiometric excess relative to the malonate compounds. Silyl ketene acetals are isolated and separated.